HitPredict

Interactor 1: MK13 (O15264)
Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
Gene: MAPK13

Interactor 2: ATF2 (P15336)
Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)
Gene: ATF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.655

Property	Details
Experiments	12244047, 10581204, 19135240
Identification Methods	enzymatic study, in-gel kinase assay, protein kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006970 - response to osmotic stress GO:0072740 - cellular response to anisomycin
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 365 Hs			1 505
+	Hs
		547811 MK14_HUMAN (1-361): 1.15e-149: 427: 60.22		ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00
+	Hs
		547709 MK03_HUMAN (12-354): 1.25e-144: 415: 43.43		ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00
+	Hs
		547713 MK01_HUMAN (12-355): 3.63e-144: 414: 42.74		ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00
+	Hs
		547805 MK11_HUMAN (1-349): 3.5e-144: 414: 60.57		ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00
+	Rn
		102456 G3V617_RAT (1-361): 2.97e-150: 429: 60.22		ATF2_RAT (19-505): 5.14e-115: 350: 98.36
+	Mm
		562973 MK14_MOUSE (1-361): 5.02e-150: 429: 60.22		ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18
+	Mm
		562985 MK11_MOUSE (1-356): 3.45e-146: 419: 59.38		ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18
+	Mm
		562975 MK01_MOUSE (12-355): 3.04e-144: 414: 42.74		ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18
+	Mm
		562980 MK03_MOUSE (15-354): 1.42e-143: 413: 43.23		ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18
+	Hs
		579344 MK14_HUMAN (1-361): 1.15e-149: 427: 60.22		ATF6A_HUMAN (145-466): 4.85e-32: 132: 14.42
+	Sp
		857024 HOG1_SCHPO (8-350): 2.84e-146: 419: 45.93		ATF1_SCHPO (174-427): 3.42e-35: 140: 26.67
+	Hs
		402080 MK14_HUMAN (1-361): 1.15e-149: 427: 60.22		JUN_HUMAN (131-423): 2.08e-32: 128: 17.78
+	Hs
		568066 MK01_HUMAN (12-355): 3.63e-144: 414: 42.74		JUND_HUMAN (154-425): 2.88e-35: 136: 19.36
+	Hs
		401456 MK03_HUMAN (12-354): 1.25e-144: 415: 43.43		JUN_HUMAN (131-423): 2.08e-32: 128: 17.78
+	Hs
		401473 MK01_HUMAN (12-355): 3.63e-144: 414: 42.74		JUN_HUMAN (131-423): 2.08e-32: 128: 17.78
+	Hs
		556876 MK14_HUMAN (1-361): 1.15e-149: 427: 60.22		CREB1_HUMAN (98-407): 1.1e-27: 115: 15.53
+	Hs
		647549 MK03_HUMAN (12-354): 1.25e-144: 415: 43.43		CREM_HUMAN (87-403): 1.03e-28: 118: 16.77
+	Dm
		248406 MK38A_DROME (1-353): 3.98e-147: 421: 57.14		JRA_DROME (156-427): 1.11e-17: 85.5: 17.65
+	Dm
		247434 MK38B_DROME (8-353): 5.47e-146: 419: 58.29		JRA_DROME (156-427): 1.11e-17: 85.5: 17.65
+	Dm
		576056 ERKA_DROME (12-350): 1.68e-140: 405: 42.78		JRA_DROME (156-427): 1.11e-17: 85.5: 17.65