HitPredict

Interactor 1: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.887

Property	Details
Experiments	17353931, 33961781, 22354967, unassigned3799
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	TLE_N~TLE_N
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0016055 - Wnt signaling pathway GO:0045892 - negative regulation of DNA-templated transcription GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 197
+	Hs
		1047798 TLE1_HUMAN (1-770): 0: 600: 100.00		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		1047795 TLE1_HUMAN (1-770): 0: 600: 100.00		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		1047797 TLE1_HUMAN (1-770): 0: 600: 100.00		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Mm
		1224207 TLE4_MOUSE (1-770): 0: 573: 86.53		TLE4_MOUSE (2-191): 3.79e-112: 338: 68.59
+	Hs
		1047951 TLE4_HUMAN (1-770): 0: 571: 86.53		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Mm
		1224201 TLE1_MOUSE (1-770): 0: 573: 96.76		TLE1_MOUSE (2-197): 2.16e-101: 310: 63.00
+	Mm
		988924 TLE1_MOUSE (1-770): 0: 573: 96.76		TLE5_MOUSE (1-197): 2.67e-101: 292: 99.49
+	Mm
		988925 TLE4_MOUSE (1-770): 0: 573: 86.53		TLE5_MOUSE (1-197): 2.67e-101: 292: 99.49
+	Hs
		1048151 TLE4_HUMAN (1-770): 0: 571: 86.53		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Hs
		1047950 TLE3_HUMAN (1-770): 1.2e-180: 537: 77.29		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		1047796 TLE1_HUMAN (1-770): 0: 600: 100.00		TLE2_HUMAN (2-149): 6.74e-80: 253: 71.62
+	Hs
		1047955 TLE3_HUMAN (1-770): 1.2e-180: 537: 77.29		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Hs
		1047993 TLE3_HUMAN (1-770): 1.2e-180: 537: 77.29		Q5T3G3_HUMAN (2-197): 1.08e-99: 290: 61.43
+	Hs
		1047891 TLE4_HUMAN (1-770): 0: 571: 86.53		TLE2_HUMAN (2-149): 6.74e-80: 253: 71.62
+	Hs
		1047991 TLE3_HUMAN (1-770): 1.2e-180: 537: 77.29		Q5JSZ1_HUMAN (2-192): 7.7e-95: 277: 63.11
+	Hs
		1047890 TLE3_HUMAN (1-770): 1.2e-180: 537: 77.29		TLE2_HUMAN (2-149): 6.74e-80: 253: 71.62