Protein: TLE2
Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)

Gene: TLE2
Organism: Homo sapiens
Interactions: 139
UniProt ID: Q04725

Gene Ontology (top 5):
GO:0003714 - transcription corepressor activity
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1047890

TLE3
Transducin-like enhancer protein 3

5

16

High-throughput

0.925

High

1047796

TLE1
Transducin-like enhancer protein 1

5

17

Small-scale

0.924

High

899354

TCPD
T-complex protein 1 subunit delta

4

20

High-throughput

0.892

High

1047891

TLE4
Transducin-like enhancer protein 4

4

18

High-throughput

0.892

High

1047896

TLE5
TLE family member 5

3

15

High-throughput

0.855

High

821316

TCPZ
T-complex protein 1 subunit zeta

4

20

High-throughput

0.797

High

881886

TCPG
T-complex protein 1 subunit gamma

4

20

High-throughput

0.797

High

1006983

TCPB
T-complex protein 1 subunit beta

4

20

High-throughput

0.797

High

1047931

TCPH
T-complex protein 1 subunit eta

4

20

High-throughput

0.797

High

899002

TCPQ
T-complex protein 1 subunit theta

3

20

High-throughput

0.765

High

610630

TCPA
T-complex protein 1 subunit alpha

2

20

High-throughput

0.694

High

875924

TCPE
T-complex protein 1 subunit epsilon

2

20

High-throughput

0.694

High

1047889

TLE2
Transducin-like enhancer protein 2

1

17

Small-scale

0.647

High

1047908

DDB1
DNA damage-binding protein 1

1

8

Small-scale

0.646

High

1047898

RIPP1
Protein ripply1

2

19

High-throughput

0.628

High

1047907

HLX
H2.0-like homeobox protein

2

20

High-throughput

0.628

High

1047913

RIPP2
Protein ripply2

2

19

High-throughput

0.628

High

1047926

TCPW
T-complex protein 1 subunit zeta-2

1

20

High-throughput

0.618

High

389310

FINC
Fibronectin

1

5

High-throughput

0.618

High

532534

CH60
60 kDa heat shock protein, mitochondrial

1

14

High-throughput

0.618

High

673859

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.618

High

969808

RS16
Small ribosomal subunit protein uS9

1

5

High-throughput

0.618

High

992699

RACK1
Small ribosomal subunit protein RACK1

1

19

High-throughput

0.618

High

1047911

DCAF6
DDB1- and CUL4-associated factor 6

1

18

High-throughput

0.618

High

1047923

CHD6
Chromodomain-helicase-DNA-binding protein 6

1

11

High-throughput

0.618

High

1047928

DDX17
Probable ATP-dependent RNA helicase DDX17

1

9

High-throughput

0.618

High

1047934

KPCD2
Serine/threonine-protein kinase D2

1

14

High-throughput

0.618

High

1047943

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

3

High-throughput

0.618

High

537018

HSP7C
Heat shock cognate 71 kDa protein

2

16

High-throughput

0.601

High

935716

MFAP4
Microfibril-associated glycoprotein 4

2

7

High-throughput

0.601

High

1047948

CHIP
E3 ubiquitin-protein ligase CHIP

2

12

High-throughput

0.601

High

1047899

PHLP
Phosducin-like protein

1

16

High-throughput

0.575

High

1047912

Q5JSZ1
TLE family member 4, transcriptional corepressor

1

15

High-throughput

0.575

High

1047935

PDCL3
Phosducin-like protein 3

1

16

High-throughput

0.575

High

159339

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

13

High-throughput

0.553

High

175013

SC16A
Protein transport protein Sec16A

1

6

High-throughput

0.553

High

1047920

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

3

High-throughput

0.553

High

1047937

STRN4
Striatin-4

1

18

High-throughput

0.553

High

1047940

DDX18
ATP-dependent RNA helicase DDX18

1

19

High-throughput

0.553

High

224982

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.541

High

330130

VENTX
Homeobox protein VENTX

1

20

High-throughput

0.541

High

703266

MSX1
Homeobox protein MSX-1

1

20

High-throughput

0.541

High

772151

MSX2
Homeobox protein MSX-2

1

20

High-throughput

0.541

High

938011

FOXA3
Hepatocyte nuclear factor 3-gamma

1

20

High-throughput

0.541

High

938436

PAX9
Paired box protein Pax-9

1

20

High-throughput

0.541

High

1047892

EMX2
Homeobox protein EMX2

1

20

High-throughput

0.541

High

1047933

BARH1
BarH-like 1 homeobox protein

1

20

High-throughput

0.541

High

930856

HSP72
Heat shock-related 70 kDa protein 2

1

16

High-throughput

0.536

High

943468

DSCR6
Protein ripply3

1

19

High-throughput

0.536

High

1047893

HME1
Homeobox protein engrailed-1

1

20

High-throughput

0.536

High

1047901

CUL4B
Cullin-4B

1

20

Small-scale

0.536

High

1047942

DNJB4
DnaJ homolog subfamily B member 4

1

8

High-throughput

0.536

High

1047945

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.536

High

1047904

HES1
Transcription factor HES-1

1

20

Small-scale

0.527

High

289138

PRDM1
PR domain zinc finger protein 1

1

5

Small-scale

0.501

High

1047944

LEF1
Lymphoid enhancer-binding factor 1

1

20

Small-scale

0.501

High

346971

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.489

High

1047946

ANR50
Ankyrin repeat domain-containing protein 50

1

7

High-throughput

0.489

High

158693

UTY
Histone demethylase UTY

1

17

Small-scale

0.481

High

123671

MYO1C
Unconventional myosin-Ic

1

11

High-throughput

0.479

High

124766

AIP
AH receptor-interacting protein

1

14

High-throughput

0.479

High

192916

CLOCK
Circadian locomoter output cycles protein kaput

1

13

High-throughput

0.479

High

257105

CCD22
Coiled-coil domain-containing protein 22

1

17

High-throughput

0.479

High

346632

TTC4
Tetratricopeptide repeat protein 4

1

20

High-throughput

0.479

High

476656

RSSA
Small ribosomal subunit protein uS2

1

3

High-throughput

0.479

High

542472

TOP2A
DNA topoisomerase 2-alpha

1

6

High-throughput

0.479

High

573441

ENPL
Endoplasmin

1

7

High-throughput

0.479

High

596059

H12
Histone H1.2

1

9

High-throughput

0.479

High

637464

FLNA
Filamin-A

1

13

High-throughput

0.479

High

640859

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

3

High-throughput

0.479

High

643797

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

4

High-throughput

0.479

High

658128

RS3
Small ribosomal subunit protein uS3

1

5

High-throughput

0.479

High

727770

DNJA1
DnaJ homolog subfamily A member 1

1

9

High-throughput

0.479

High

756157

MCM7
DNA replication licensing factor MCM7

1

7

High-throughput

0.479

High

770158

RL22
Large ribosomal subunit protein eL22

1

4

High-throughput

0.479

High

824114

RL13A
Large ribosomal subunit protein uL13

1

5

High-throughput

0.479

High

834432

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

7

High-throughput

0.479

High

842199

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

5

High-throughput

0.479

High

858896

RL27A
Large ribosomal subunit protein uL15

1

5

High-throughput

0.479

High

860171

RS9
Small ribosomal subunit protein uS4

1

5

High-throughput

0.479

High

956710

RAB10
Ras-related protein Rab-10

1

3

High-throughput

0.479

High

960090

RL26
Large ribosomal subunit protein uL24

1

4

High-throughput

0.479

High

967406

RS7
Small ribosomal subunit protein eS7

1

3

High-throughput

0.479

High

972371

RS14
Small ribosomal subunit protein uS11

1

5

High-throughput

0.479

High

973148

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.479

High

973406

RS11
Small ribosomal subunit protein uS17

1

5

High-throughput

0.479

High

977209

RS4X
Small ribosomal subunit protein eS4, X isoform

1

4

High-throughput

0.479

High

981797

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.479

High

982926

RS25
Small ribosomal subunit protein eS25

1

3

High-throughput

0.479

High

985622

RL11
Large ribosomal subunit protein uL5

1

3

High-throughput

0.479

High

992469

RS21
Small ribosomal subunit protein eS21

1

1

High-throughput

0.479

High

1025992

CLH1
Clathrin heavy chain 1

1

5

High-throughput

0.479

High

1032288

OTUD4
OTU domain-containing protein 4

1

6

High-throughput

0.479

High

1047894

RL18
Large ribosomal subunit protein eL18

1

4

High-throughput

0.479

High

1047900

CUL4A
Cullin-4A

1

20

Small-scale

0.479

High

1047902

RIN1
Ras and Rab interactor 1

1

4

High-throughput

0.479

High

1047903

KEAP1
Kelch-like ECH-associated protein 1

1

4

High-throughput

0.479

High

1047906

MVP
Major vault protein

1

2

High-throughput

0.479

High

1047914

STRP1
Striatin-interacting protein 1

1

2

High-throughput

0.479

High

1047916

THOC7
THO complex subunit 7

1

1

High-throughput

0.479

High

1047917

CAVN1
Caveolae-associated protein 1

1

1

High-throughput

0.479

High

1047922

GCC2
GRIP and coiled-coil domain-containing protein 2

1

14

High-throughput

0.479

High

1047924

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

5

High-throughput

0.479

High

1047925

DCAF4
DDB1- and CUL4-associated factor 4

1

2

High-throughput

0.479

High

1047927

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

4

High-throughput

0.479

High

1047930

DNJC7
DnaJ homolog subfamily C member 7

1

20

High-throughput

0.479

High

1047932

GNL3
Guanine nucleotide-binding protein-like 3

1

9

High-throughput

0.479

High

1047947

PRP19
Pre-mRNA-processing factor 19

1

17

High-throughput

0.479

High

1047949

NUDC
Nuclear migration protein nudC

1

19

High-throughput

0.479

High

516194

HS71B
Heat shock 70 kDa protein 1B

1

16

High-throughput

0.445

High

1047929

PFD5
Prefoldin subunit 5

1

11

High-throughput

0.445

High

176665

PUR4
Phosphoribosylformylglycinamidine synthase

1

1

High-throughput

0.437

High

182117

PFD6
Prefoldin subunit 6

1

6

High-throughput

0.437

High

258844

DNJA2
DnaJ homolog subfamily A member 2

1

9

High-throughput

0.437

High

425902

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

17

High-throughput

0.437

High

576755

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

6

High-throughput

0.437

High

680325

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

6

High-throughput

0.437

High

733912

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

3

High-throughput

0.437

High

859579

RL21
Large ribosomal subunit protein eL21

1

2

High-throughput

0.437

High

882639

EFTU
Elongation factor Tu, mitochondrial

1

5

High-throughput

0.437

High

940226

SYMC
Methionine--tRNA ligase, cytoplasmic

1

8

High-throughput

0.437

High

985443

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.437

High

1004257

F193A
Protein FAM193A

1

1

High-throughput

0.437

High

1047895

ZO1
Tight junction protein 1

1

8

High-throughput

0.437

High

1047897

DSC1
Desmocollin-1

1

3

High-throughput

0.437

High

1047905

GANAB
Neutral alpha-glucosidase AB

1

2

High-throughput

0.437

High

1047909

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

1

3

High-throughput

0.437

High

1047910

CEP55
Centrosomal protein of 55 kDa

1

1

High-throughput

0.437

High

1047915

ANR40
Ankyrin repeat domain-containing protein 40

1

2

High-throughput

0.437

High

1047918

CEP85
Centrosomal protein of 85 kDa

1

20

High-throughput

0.437

High

1047919

STXB4
Syntaxin-binding protein 4

1

9

High-throughput

0.437

High

1047921

NUP54
Nucleoporin p54

1

7

High-throughput

0.437

High

1047936

WDCP
WD repeat and coiled-coil-containing protein

1

1

High-throughput

0.437

High

1047938

KIF15
Kinesin-like protein KIF15

1

4

High-throughput

0.437

High

1047941

ANFY1
Rabankyrin-5

1

8

High-throughput

0.437

High

1047939

CNBP1
Beta-catenin-interacting protein 1

1

0

High-throughput

0.426

High

298847

LYZL6
Lysozyme-like protein 6

1

1

High-throughput

0.407

High

60327

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025