HitPredict

Interactor 1: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	17353931, 24981860, 33961781, 37689310, 40437099
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	TLE_N~TLE_N
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0016055 - Wnt signaling pathway GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 772 Hs			1 197
+	Hs
		1047951 TLE3_HUMAN (1-772): 0: 597: 100.00		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		1047797 TLE3_HUMAN (1-772): 0: 597: 100.00		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		1047950 TLE3_HUMAN (1-772): 0: 597: 100.00		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		1047798 TLE1_HUMAN (1-772): 0: 553: 77.96		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		1047795 TLE1_HUMAN (1-772): 0: 553: 77.96		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		1047993 TLE3_HUMAN (1-772): 0: 597: 100.00		Q5T3G3_HUMAN (2-197): 1.08e-99: 290: 61.43
+	Mm
		1224207 TLE4_MOUSE (1-772): 0: 542: 80.65		TLE4_MOUSE (2-191): 3.79e-112: 338: 68.59
+	Hs
		1047991 TLE3_HUMAN (1-772): 0: 597: 100.00		Q5JSZ1_HUMAN (2-192): 7.7e-95: 277: 63.11
+	Hs
		1047890 TLE3_HUMAN (1-772): 0: 597: 100.00		TLE2_HUMAN (2-149): 6.74e-80: 253: 71.62
+	Hs
		1047802 TLE1_HUMAN (1-772): 0: 553: 77.96		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Mm
		1224201 TLE1_MOUSE (1-772): 5.96e-180: 535: 78.09		TLE1_MOUSE (2-197): 2.16e-101: 310: 63.00
+	Mm
		988925 TLE4_MOUSE (1-772): 0: 542: 80.65		TLE5_MOUSE (1-197): 2.67e-101: 292: 99.49
+	Hs
		1048151 TLE4_HUMAN (1-772): 0: 541: 80.52		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Mm
		988924 TLE1_MOUSE (1-772): 5.96e-180: 535: 78.09		TLE5_MOUSE (1-197): 2.67e-101: 292: 99.49
+	Hs
		1047796 TLE1_HUMAN (1-772): 0: 553: 77.96		TLE2_HUMAN (2-149): 6.74e-80: 253: 71.62
+	Hs
		1047891 TLE4_HUMAN (1-772): 0: 541: 80.52		TLE2_HUMAN (2-149): 6.74e-80: 253: 71.62