HitPredict

Interactor 1: TLE2 (Q04725)
Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)
Gene: TLE2

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	24981860, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	TLE_N~TLE_N
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0016055 - Wnt signaling pathway GO:0045892 - negative regulation of DNA-templated transcription GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 743 Hs			1 197
+	Hs
		1047891 TLE2_HUMAN (1-743): 1.19e-176: 525: 100.00		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		1047796 TLE2_HUMAN (1-743): 1.19e-176: 525: 100.00		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		1047890 TLE2_HUMAN (1-743): 1.19e-176: 525: 100.00		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		1047798 TLE1_HUMAN (1-743): 7.26e-167: 501: 65.98		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Mm
		1224207 TLE4_MOUSE (1-743): 8.38e-167: 501: 66.71		TLE4_MOUSE (2-191): 3.79e-112: 338: 68.59
+	Hs
		1047795 TLE1_HUMAN (1-743): 7.26e-167: 501: 65.98		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		1047797 TLE1_HUMAN (1-743): 7.26e-167: 501: 65.98		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		1047951 TLE4_HUMAN (1-743): 3.11e-166: 499: 65.93		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Mm
		1224201 TLE1_MOUSE (1-743): 3.6e-164: 494: 63.25		TLE1_MOUSE (2-197): 2.16e-101: 310: 63.00
+	Hs
		1047912 TLE2_HUMAN (1-743): 1.19e-176: 525: 100.00		Q5JSZ1_HUMAN (2-192): 7.7e-95: 277: 63.11
+	Hs
		1047802 TLE1_HUMAN (1-743): 7.26e-167: 501: 65.98		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Mm
		988925 TLE4_MOUSE (1-743): 8.38e-167: 501: 66.71		TLE5_MOUSE (1-197): 2.67e-101: 292: 99.49
+	Hs
		1048151 TLE4_HUMAN (1-743): 3.11e-166: 499: 65.93		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Mm
		988924 TLE1_MOUSE (1-743): 3.6e-164: 494: 63.25		TLE5_MOUSE (1-197): 2.67e-101: 292: 99.49
+	Hs
		1047889 TLE2_HUMAN (1-743): 1.19e-176: 525: 100.00		TLE2_HUMAN (2-149): 6.74e-80: 253: 71.62