HitPredict

Interactor 1: EIF3A (Q14152)
Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185)
Gene: EIF3A

Interactor 2: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0014069 - postsynaptic density GO:0016020 - membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1382 Hs			1 1164
+	Hs
		1034608 GOGA4_HUMAN (70-1382): 7.95e-38: 157: 9.14		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Hs
		148797 EIF3A_HUMAN (1-1382): 3.42e-120: 410: 100.00		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Dm
		1362779 EIF3A_DROME (1-887): 3.81e-75: 275: 49.27		Q9VCC9_DROME (835-1160): 2.53e-09: 63.7: 9.76
+	Hs
		724943 MYH9_HUMAN (55-1098): 6.44e-45: 180: 9.65		MY18A_HUMAN (461-1064): 4e-25: 115: 10.31
+	Hs
		724686 MYH9_HUMAN (55-1098): 6.44e-45: 180: 9.65		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		148460 MYH9_HUMAN (55-1098): 6.44e-45: 180: 9.65		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		1035214 ITSN2_HUMAN (542-870): 1.01e-49: 196: 21.46		ROCK1_HUMAN (433-926): 6.18e-15: 82.2: 12.00
+	Hs
		725097 MYH10_HUMAN (46-929): 1.09e-34: 147: 10.53		MYH11_HUMAN (392-1122): 2.73e-28: 126: 8.64
+	Hs
		148769 GOGA4_HUMAN (70-1382): 7.95e-38: 157: 9.14		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		724810 MYH9_HUMAN (55-1098): 6.44e-45: 180: 9.65		ROCK1_HUMAN (433-926): 6.18e-15: 82.2: 12.00
+	Mm
		93570 MYH9_MOUSE (55-1069): 2.38e-45: 182: 10.19		DESP_MOUSE (718-1164): 2.9e-13: 77.2: 10.89
+	Dm
		1303379 MYSN_DROME (5-1099): 2.27e-39: 162: 9.78		MYSN_DROME (417-1038): 2.47e-19: 96.8: 9.88
+	Hs
		148461 MYH10_HUMAN (46-929): 1.09e-34: 147: 10.53		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		724861 MYH9_HUMAN (55-1098): 6.44e-45: 180: 9.65		CYTSB_HUMAN (740-1117): 1.86e-12: 74.1: 12.41
+	Hs
		724895 MYH9_HUMAN (55-1098): 6.44e-45: 180: 9.65		MYH14_HUMAN (620-918): 1.78e-11: 71.1: 13.11
+	Hs
		724687 MYH9_HUMAN (55-1098): 6.44e-45: 180: 9.65		MYH10_HUMAN (687-992): 3.26e-09: 63.6: 20.43
+	Hs
		725174 MYH10_HUMAN (46-929): 1.09e-34: 147: 10.53		CYTSB_HUMAN (740-1117): 1.86e-12: 74.1: 12.41
+	Hs
		725189 MYH10_HUMAN (46-929): 1.09e-34: 147: 10.53		MYH14_HUMAN (620-918): 1.78e-11: 71.1: 13.11
+	Hs
		725095 MYH10_HUMAN (46-929): 1.09e-34: 147: 10.53		MYH10_HUMAN (687-992): 3.26e-09: 63.6: 20.43