HitPredict

Interactor 1: FAK2 (Q14289)
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
Gene: PTK2B

Interactor 2: GIT1 (Q9Y2X7)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)
Gene: GIT1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12629171
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0014069 - postsynaptic density GO:0030027 - lamellipodium GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1009 Hs			1 761
+	Hs
		983697 FAK1_HUMAN (39-1000): 0: 846: 44.25		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Mm
		1351539 FAK2_MOUSE (1-1009): 0: 1035: 95.44		ASAP1_MOUSE (2-606): 1.61e-70: 253: 17.54
+	Hs
		195794 FAK2_HUMAN (1-1009): 0: 1064: 100.00		ASAP2_HUMAN (2-506): 1.34e-50: 193: 15.20
+	Mm
		1112655 FAK2_MOUSE (1-1009): 0: 1035: 95.44		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Mm
		93394 E9Q2A6_MOUSE (1-1009): 0: 991: 91.28		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Hs
		983689 FAK1_HUMAN (39-1000): 0: 846: 44.25		ASAP1_HUMAN (2-606): 1.67e-61: 226: 17.06
+	Mm
		710137 FAK1_MOUSE (39-1000): 0: 840: 44.15		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Hs
		983635 FAK1_HUMAN (39-1000): 0: 846: 44.25		ANKH1_HUMAN (50-650): 2.73e-32: 137: 9.53
+	Hs
		665371 EPHA2_HUMAN (362-719): 1.23e-115: 381: 32.04		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Hs
		337590 ABL1_HUMAN (264-885): 2.55e-133: 432: 23.56		ASAP1_HUMAN (2-606): 1.67e-61: 226: 17.06
+	Hs
		337477 ABL1_HUMAN (264-885): 2.55e-133: 432: 23.56		ACAP1_HUMAN (2-297): 2.23e-56: 208: 23.77
+	Mm
		1142639 ERBB4_MOUSE (280-925): 7.79e-130: 426: 23.60		ASAP2_MOUSE (2-455): 5.97e-51: 194: 17.62
+	Mm
		70554 B2RQ57_MOUSE (276-893): 1.22e-127: 416: 23.67		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Hs
		789012 TEC_HUMAN (301-688): 9.38e-118: 377: 26.46		ASAP1_HUMAN (2-606): 1.67e-61: 226: 17.06
+	Hs
		523197 SRC_HUMAN (288-695): 5.62e-117: 371: 27.74		ASAP1_HUMAN (2-606): 1.67e-61: 226: 17.06
+	Hs
		411807 LCK_HUMAN (208-694): 1.45e-123: 387: 27.18		ARAP2_HUMAN (7-223): 6.18e-51: 195: 27.15
+	Hs
		523208 SRC_HUMAN (288-695): 5.62e-117: 371: 27.74		AGAP1_HUMAN (2-223): 4.13e-57: 211: 32.89
+	Hs
		522992 SRC_HUMAN (288-695): 5.62e-117: 371: 27.74		ACAP1_HUMAN (2-297): 2.23e-56: 208: 23.77
+	Hs
		195782 SRC_HUMAN (288-695): 5.62e-117: 371: 27.74		ASAP2_HUMAN (2-506): 1.34e-50: 193: 15.20
+	Hs
		411697 LCK_HUMAN (208-694): 1.45e-123: 387: 27.18		ANK3_HUMAN (93-695): 4.85e-40: 162: 12.34