HitPredict

Interactor 1: PAX8 (Q06710)
Paired box protein Pax-8
Gene: PAX8

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.653

Property	Details
Experiments	32296183, 35140242, unassigned1304
Identification Methods	two hybrid, proximity labelling technology, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 450 Hs			1 197
+	Hs
		1048150 PAX8_HUMAN (1-450): 2.29e-110: 334: 100.00		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		1047800 PAX8_HUMAN (1-450): 2.29e-110: 334: 100.00		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		1047954 PAX8_HUMAN (1-450): 2.29e-110: 334: 100.00		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		685164 PAX6_HUMAN (6-413): 5.27e-95: 294: 31.99		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		685162 PAX6_HUMAN (6-413): 5.27e-95: 294: 31.99		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Mm
		666052 PAX3_MOUSE (9-446): 1.74e-92: 289: 32.01		TLE4_MOUSE (2-191): 3.79e-112: 338: 68.59
+	Hs
		662217 PAX7_HUMAN (9-446): 1.59e-88: 280: 28.41		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		662215 PAX7_HUMAN (9-446): 1.59e-88: 280: 28.41		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		685163 PAX6_HUMAN (6-413): 5.27e-95: 294: 31.99		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		1040040 PAX2_HUMAN (2-368): 3.93e-85: 268: 52.42		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		662216 PAX7_HUMAN (9-446): 1.59e-88: 280: 28.41		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		1037712 PAX5_HUMAN (5-368): 3.23e-81: 258: 47.83		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		1040041 PAX2_HUMAN (2-368): 3.93e-85: 268: 52.42		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		685170 PAX6_HUMAN (6-413): 5.27e-95: 294: 31.99		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Hs
		662219 PAX7_HUMAN (9-446): 1.59e-88: 280: 28.41		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Hs
		1040044 PAX2_HUMAN (2-368): 3.93e-85: 268: 52.42		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Hs
		938435 PAX9_HUMAN (6-346): 7.39e-65: 214: 33.33		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		938437 PAX9_HUMAN (6-346): 7.39e-65: 214: 33.33		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		938436 PAX9_HUMAN (6-346): 7.39e-65: 214: 33.33		TLE2_HUMAN (2-149): 6.74e-80: 253: 71.62
+	Ce
		111450 PAX3H_CAEEL (9-333): 4.45e-75: 239: 30.68		UNC37_CAEEL (18-160): 8.47e-43: 153: 28.47