HitPredict

Interactor 1: NUMA1 (Q14980)
Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Gene: NUMA1

Interactor 2: WDR76 (Q9H967)
WD repeat-containing protein 76
Gene: WDR76

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	27248496, 31353912, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2115 Hs			1 626
+	Hs
		1061201 NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00		FBXW7_HUMAN (180-616): 3.15e-66: 231: 11.79
+	Hs
		1061204 NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00		SNR40_HUMAN (440-625): 1.07e-33: 134: 11.83
+	Hs
		997728 NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55
+	Hs
		725024 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		WDR76_HUMAN (1-626): 1.19e-151: 453: 100.00
+	Hs
		725247 MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34		WDR76_HUMAN (1-626): 1.19e-151: 453: 100.00
+	Hs
		1068668 PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37		WDR76_HUMAN (1-626): 1.19e-151: 453: 100.00
+	Hs
		1067473 EEA1_HUMAN (964-1838): 2.18e-28: 127: 12.15		WDR76_HUMAN (1-626): 1.19e-151: 453: 100.00
+	Hs
		197084 CP250_HUMAN (1-1659): 6.01e-59: 228: 13.08		PRP4_HUMAN (401-624): 5.45e-40: 155: 15.09
+	Hs
		724952 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		FBXW7_HUMAN (180-616): 3.15e-66: 231: 11.79
+	Hs
		725215 MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34		FBXW7_HUMAN (180-616): 3.15e-66: 231: 11.79
+	Hs
		1068625 PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37		FBXW7_HUMAN (180-616): 3.15e-66: 231: 11.79
+	Hs
		1067456 EEA1_HUMAN (964-1838): 2.18e-28: 127: 12.15		FBXW7_HUMAN (180-616): 3.15e-66: 231: 11.79
+	Hs
		792973 CENPE_HUMAN (694-2076): 2.24e-41: 170: 9.63		LIS1_HUMAN (118-478): 6.33e-51: 183: 9.73
+	Hs
		518898 TPR_HUMAN (2-620): 2.42e-18: 94.7: 12.04		COP1_HUMAN (154-619): 7.6e-71: 245: 14.96
+	Hs
		997881 CP250_HUMAN (1-1659): 6.01e-59: 228: 13.08		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55
+	Mm
		925837 Q155P7_MOUSE (562-1890): 5.59e-30: 133: 11.42		LIS1_MOUSE (118-478): 1.34e-50: 182: 9.73
+	Hs
		903240 PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37		WDR5_HUMAN (435-622): 2.2e-42: 157: 12.23
+	Hs
		728492 MYH11_HUMAN (1430-2076): 4.75e-22: 107: 8.41		POC1A_HUMAN (391-623): 1.51e-49: 179: 12.45
+	Hs
		903233 GOGB1_HUMAN (1105-2077): 1.12e-19: 99.3: 9.49		WDR5_HUMAN (435-622): 2.2e-42: 157: 12.23
+	Hs
		518846 TPR_HUMAN (2-620): 2.42e-18: 94.7: 12.04		WDR5_HUMAN (435-622): 2.2e-42: 157: 12.23