HitPredict

Interactor 1: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Interactor 2: ISX (Q2M1V0)
Intestine-specific homeobox (RAX-like homeobox)
Gene: ISX

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 197 Hs			1 245
+	Hs
		1048161 TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59		ISX_HUMAN (1-245): 1.49e-56: 182: 100.00
+	Hs
		1047831 TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50		ISX_HUMAN (1-245): 1.49e-56: 182: 100.00
+	Hs
		1047983 TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50		ISX_HUMAN (1-245): 1.49e-56: 182: 100.00
+	Mm
		666052 TLE4_MOUSE (2-191): 3.79e-112: 338: 68.59		PAX3_MOUSE (56-245): 2.44e-32: 124: 27.37
+	Hs
		662217 TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59		PAX7_HUMAN (65-245): 2.77e-30: 119: 30.06
+	Hs
		895705 TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50		LHX2_HUMAN (23-227): 2.86e-31: 120: 22.44
+	Hs
		662215 TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50		PAX7_HUMAN (65-245): 2.77e-30: 119: 30.06
+	Hs
		685164 TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59		PAX6_HUMAN (36-236): 1.72e-29: 116: 25.37
+	Hs
		685162 TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50		PAX6_HUMAN (36-236): 1.72e-29: 116: 25.37
+	Hs
		662216 TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50		PAX7_HUMAN (65-245): 2.77e-30: 119: 30.06
+	Hs
		685163 TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50		PAX6_HUMAN (36-236): 1.72e-29: 116: 25.37
+	Hs
		1061841 TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00		PITX2_HUMAN (37-216): 4.44e-37: 134: 26.74
+	Hs
		1048182 TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59		VSX1_HUMAN (72-142): 4.52e-18: 84: 59.16
+	Hs
		1047876 TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50		VSX1_HUMAN (72-142): 4.52e-18: 84: 59.16
+	Hs
		1005578 TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00		PITX1_HUMAN (34-236): 1.16e-32: 122: 27.05
+	Hs
		895708 TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00		LHX2_HUMAN (23-227): 2.86e-31: 120: 22.44
+	Hs
		662219 TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00		PAX7_HUMAN (65-245): 2.77e-30: 119: 30.06
+	Hs
		685170 TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00		PAX6_HUMAN (36-236): 1.72e-29: 116: 25.37
+	Hs
		1048115 TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50		VSX1_HUMAN (72-142): 4.52e-18: 84: 59.16
+	Hs
		1061835 TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00		ARX_HUMAN (79-144): 1.55e-17: 83.2: 63.64