HitPredict

Interactor 1: CPSF1 (Q10570)
Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)
Gene: CPSF1

Interactor 2: CPSF2 (Q9P2I0)
Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit)
Gene: CPSF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	29395067, 24981860, 33469008
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1443 Hs			1 782
+	Hs
		1083455 CPSF1_HUMAN (1-1443): 0: 1602: 100.00		CPSF3_HUMAN (2-558): 1.86e-173: 516: 21.28
+	At
		1425111 CPSF1_ARATH (2-1442): 0: 1072: 29.98		CPSF2_ARATH (1-782): 0: 714: 36.89
+	Sp
		267957 CFT1_SCHPO (1-1442): 0: 1040: 25.13		CFT2_SCHPO (22-782): 0: 594: 30.09
+	At
		1422837 CPSF1_ARATH (2-1442): 0: 1072: 29.98		CPSF3_ARATH (2-576): 4.65e-174: 518: 19.97
+	At
		1299020 CPSF1_ARATH (2-1442): 0: 1072: 29.98		CPS3B_ARATH (4-567): 3.85e-160: 480: 19.10
+	Sp
		151392 CFT1_SCHPO (1-1442): 0: 1040: 25.13		YSH1_SCHPO (2-540): 3.19e-158: 480: 21.28
+	Sc
		1056342 CFT1_YEAST (3-678): 9.86e-115: 395: 18.62		CFT2_YEAST (1-780): 7.21e-156: 477: 20.61
+	Sc
		1054424 CFT1_YEAST (3-678): 9.86e-115: 395: 18.62		YSH1_YEAST (2-538): 1.74e-145: 447: 21.07