HitPredict

Interactor 1: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Interactor 2: EGLN3 (Q9H6Z9)
Prolyl hydroxylase EGLN3 (EC 1.14.11.-) (Egl nine homolog 3) (EC 1.14.11.29) (HPH-1) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3)
Gene: EGLN3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 26972000, 16155211, 17069766, 18063574, 30067985, 31239290, 18402654, 25416956, 17353276, 15721254, 18264140, 24015760, 24145445, 31515488, 15474027, 16511565
Identification Methods affinity chromatography technology, enzymatic study, two hybrid, pull down, anti tag coimmunoprecipitation, two hybrid array, experimental interaction detection, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association, hydroxylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains 2OG-FeII_Oxy_3~HIF-1
Common GO terms GO:0001666 - response to hypoxia
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 1 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 826
Hs

1 239
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Last updated: 15 Jul 2024