HitPredict

Interactor 1: H2A2C (Q16777)
Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)
Gene: H2AC20

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.964

Property	Details
Experiments	16714294, 16943429, 25519132, 25470042, 26936624, 15386022, 20351251, 21772249
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 129 Hs			1 336
+	Hs
		1216249 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		1151374 H2A2A_HUMAN (1-127): 3.37e-65: 195: 97.64		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		1185208 H2A3_HUMAN (1-127): 5.35e-65: 195: 95.28		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		470514 H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		391856 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		391666 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		555425 H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		470533 H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		717876 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		391879 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		470285 H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		717932 H2A2A_HUMAN (1-127): 3.37e-65: 195: 97.64		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		391572 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		555322 H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		1087090 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		391861 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		749544 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		391581 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		555327 H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		551444 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		RAG1_HUMAN (42-197): 1.72e-29: 121: 20.51