HitPredict

Interactor 1: F263 (Q16875)
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]
Gene: PFKFB3

Interactor 2: F264 (Q16877)
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase 4) (PFK/FBPase 4) (6PF-2-K/Fru-2,6-P2ase testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]
Gene: PFKFB4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 28514442, 33961781, 36115843
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains 6PF2K~6PF2K, 6PF2K~His_Phos_1, His_Phos_1~His_Phos_1
Common GO terms GO:0003873 - 6-phosphofructo-2-kinase activity
GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006000 - fructose metabolic process
and 1 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 520
Hs

1 469
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Last updated: 15 Jul 2024