Protein: PHF6
PHD finger protein 6 (PHD-like zinc finger protein)

Gene: PHF6
Organism: Homo sapiens
Interactions: 166
UniProt ID: Q8IWS0

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000776 - kinetochore
GO:0001835 - blastocyst hatching
GO:0003677 - DNA binding
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

372508

MYC
Myc proto-oncogene protein

4

9

High-throughput

0.672

High

1310737

LYAR
Cell growth-regulating nucleolar protein

3

1

Small-scale

0.640

High

1066381

RBBP4
Histone-binding protein RBBP4

2

18

Small-scale

0.639

High

1006527

SRPK2
SRSF protein kinase 2

2

5

High-throughput

0.619

High

1113626

CUL3
Cullin-3

2

6

High-throughput

0.611

High

1115793

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

9

High-throughput

0.611

High

242211

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

260153

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.584

High

447197

NPM
Nucleophosmin

2

3

Small-scale

0.584

High

754905

H2B1B
Histone H2B type 1-B

2

20

Small-scale

0.584

High

396463

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

471121

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.536

High

502418

H2A1
Histone H2A type 1

1

11

High-throughput

0.536

High

521795

H14
Histone H1.4

1

7

High-throughput

0.536

High

686254

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.536

High

693834

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.536

High

961613

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

1

High-throughput

0.536

High

1088902

TP53B
TP53-binding protein 1

1

3

High-throughput

0.536

High

1104319

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.536

High

1310720

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

1

High-throughput

0.536

High

1310740

DAXX
Death domain-associated protein 6

1

4

High-throughput

0.536

High

1257018

SYDE1
Rho GTPase-activating protein SYDE1

2

5

High-throughput

0.521

High

969298

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.513

High

979044

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.513

High

1246062

CPLX2
Complexin-2

1

0

High-throughput

0.513

High

1291048

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

185837

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

8

High-throughput

0.501

High

1310724

KLF16
Krueppel-like factor 16

1

14

High-throughput

0.500

High

1038453

TIE2
Angiopoietin-1 receptor

1

9

High-throughput

0.489

High

279414

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

289605

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

5

Small-scale

0.479

High

315758

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

346041

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

401111

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

404200

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

406362

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.479

High

419069

H2A1B
Histone H2A type 1-B/E

1

11

High-throughput

0.479

High

428845

RLA0
Large ribosomal subunit protein uL10

1

2

Small-scale

0.479

High

462502

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

7

Small-scale

0.479

High

472873

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

487503

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

502047

H2AZ
Histone H2A.Z

1

15

Small-scale

0.479

High

519400

MYB
Transcriptional activator Myb

1

4

High-throughput

0.479

High

596212

H12
Histone H1.2

1

7

Small-scale

0.479

High

643923

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

Small-scale

0.479

High

650846

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

Small-scale

0.479

High

729079

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

2

Small-scale

0.479

High

731443

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

765684

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.479

High

766678

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

770224

RL22
Large ribosomal subunit protein eL22

1

1

Small-scale

0.479

High

778078

VGFR2
Vascular endothelial growth factor receptor 2

1

5

High-throughput

0.479

High

788705

SRP14
Signal recognition particle 14 kDa protein

1

1

Small-scale

0.479

High

799971

COIL
Coilin

1

5

High-throughput

0.479

High

871971

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

2

High-throughput

0.479

High

876924

KC1A
Casein kinase I isoform alpha

1

2

High-throughput

0.479

High

879253

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

High-throughput

0.479

High

885831

KC1E
Casein kinase I isoform epsilon

1

5

High-throughput

0.479

High

908420

HDGF
Hepatoma-derived growth factor

1

5

High-throughput

0.479

High

909622

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

3

Small-scale

0.479

High

937812

FOXA1
Hepatocyte nuclear factor 3-alpha

1

9

High-throughput

0.479

High

962245

RHOA
Transforming protein RhoA

1

3

High-throughput

0.479

High

970745

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

979945

H4
Histone H4

1

13

High-throughput

0.479

High

980906

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.479

High

984461

RL30
Large ribosomal subunit protein eL30

1

1

Small-scale

0.479

High

988508

RAC1
Ras-related C3 botulinum toxin substrate 1

1

4

High-throughput

0.479

High

1004796

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1017006

H33
Histone H3.3

1

20

High-throughput

0.479

High

1027576

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

13

Small-scale

0.479

High

1040845

MECOM
Histone-lysine N-methyltransferase MECOM

1

2

High-throughput

0.479

High

1045483

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

1067493

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

1088433

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

11

Small-scale

0.479

High

1107004

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1107893

SQSTM
Sequestosome-1

1

5

High-throughput

0.479

High

1109873

HDAC1
Histone deacetylase 1

1

13

Small-scale

0.479

High

1124362

ELOA1
Elongin-A

1

3

High-throughput

0.479

High

1132811

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

11

Small-scale

0.479

High

1137838

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

1146940

PCBP2
Poly(rC)-binding protein 2

1

2

Small-scale

0.479

High

1158912

RBBP7
Histone-binding protein RBBP7

1

18

Small-scale

0.479

High

1194203

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

1215697

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1254537

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.479

High

1271726

MEPCE
7SK snRNA methylphosphate capping enzyme

1

2

High-throughput

0.479

High

1289440

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1310704

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

1310707

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

5

High-throughput

0.479

High

1310712

PHIP
PH-interacting protein

1

20

Small-scale

0.479

High

1310714

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1310715

FBXW7
F-box/WD repeat-containing protein 7

1

13

High-throughput

0.479

High

1310719

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1310722

TBA1C
Tubulin alpha-1C chain

1

1

Small-scale

0.479

High

1310726

TRI31
E3 ubiquitin-protein ligase TRIM31

1

10

High-throughput

0.479

High

1310731

WDR76
WD repeat-containing protein 76

1

20

High-throughput

0.479

High

1310733

RC3H2
Roquin-2

1

13

High-throughput

0.479

High

1310734

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

4

High-throughput

0.479

High

1310735

BRD7
Bromodomain-containing protein 7

1

17

High-throughput

0.479

High

1310741

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1310743

RALY
RNA-binding protein Raly

1

4

Small-scale

0.479

High

1310745

FZR1
Fizzy-related protein homolog

1

19

High-throughput

0.479

High

1310748

ZN330
Zinc finger protein 330

1

7

High-throughput

0.479

High

171892

ZN263
Zinc finger protein 263

1

0

Small-scale

0.458

High

194258

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

247992

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

319889

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

320718

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

553006

PIP
Prolactin-inducible protein

1

0

Small-scale

0.458

High

629954

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

785280

RL4
Large ribosomal subunit protein uL4

1

0

Small-scale

0.458

High

831029

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

961058

MGN
Protein mago nashi homolog

1

0

Small-scale

0.458

High

972903

RS18
Small ribosomal subunit protein uS13

1

0

Small-scale

0.458

High

982991

RS25
Small ribosomal subunit protein eS25

1

0

Small-scale

0.458

High

992503

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.458

High

1197635

MIDN
Midnolin

1

0

High-throughput

0.458

High

1241679

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

Small-scale

0.458

High

1310705

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

1310716

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

1310717

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.458

High

1310728

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1310736

ANLN
Anillin

1

0

High-throughput

0.458

High

1310742

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.458

High

711913

LTK
Leukocyte tyrosine kinase receptor

1

7

High-throughput

0.457

High

430108

JUN
Transcription factor Jun

1

11

High-throughput

0.445

High

1009243

PRR3
Proline-rich protein 3

1

1

High-throughput

0.445

High

1016507

SRSF3
Serine/arginine-rich splicing factor 3

1

6

High-throughput

0.445

High

1112078

KRR1
KRR1 small subunit processome component homolog

1

1

High-throughput

0.445

High

1132386

CASP8
Caspase-8

1

6

High-throughput

0.445

High

1310710

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.445

High

1310732

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

293981

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

412220

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

477242

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

11

High-throughput

0.437

High

610017

VGFR1
Vascular endothelial growth factor receptor 1

1

5

High-throughput

0.437

High

650284

FGFR3
Fibroblast growth factor receptor 3

1

8

High-throughput

0.437

High

720272

UFO
Tyrosine-protein kinase receptor UFO

1

3

High-throughput

0.437

High

720504

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.437

High

787043

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

5

High-throughput

0.437

High

955357

CDC42
Cell division control protein 42 homolog

1

4

High-throughput

0.437

High

1087669

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

5

High-throughput

0.437

High

1213065

RHG21
Rho GTPase-activating protein 21

1

2

High-throughput

0.437

High

1310706

FBXL6
F-box/LRR-repeat protein 6

1

3

High-throughput

0.437

High

1310708

KDF1
Keratinocyte differentiation factor 1

1

1

High-throughput

0.437

High

1310721

LMTK3
Serine/threonine-protein kinase LMTK3

1

12

High-throughput

0.437

High

1310723

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.437

High

1310725

RHBT2
Rho-related BTB domain-containing protein 2

1

4

High-throughput

0.437

High

1310729

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1310738

HECW2
E3 ubiquitin-protein ligase HECW2

1

4

High-throughput

0.437

High

1310744

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.437

High

181139

AXIN1
Axin-1

1

0

Small-scale

0.426

High

1310703

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

0

High-throughput

0.426

High

1310739

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.426

High

887008

CEBPA
CCAAT/enhancer-binding protein alpha

1

13

High-throughput

0.408

High

1197816

S39AC
Zinc transporter ZIP12

1

2

High-throughput

0.407

High

932737

EMP3
Epithelial membrane protein 3

1

0

High-throughput

0.279

Low

1310713

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.279

Low

1310718

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

1310746

KLH20
Kelch-like protein 20

1

0

High-throughput

0.279

Low

1310747

AP3M1
AP-3 complex subunit mu-1

1

0

High-throughput

0.279

Low

1310709

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

1310711

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1310727

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.249

Low

1155075

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

1310730

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025