Interactor 1: ULA1 (Q18217)
NEDD8-activating enzyme E1 regulatory subunit (Ubiquitin-like activation protein 1)
Gene: ula-1

Interactor 2: UBA3 (Q19360)
NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (Ectopic membrane ruffles in embryo protein 1) (Ubiquitin-activating enzyme 3 homolog)
Gene: rfl-1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.34 1.00 0.590

The method score is based on:

Property Details
Experiments 11731503
Identification Methods two hybrid
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains E2_bind~ThiF, ThiF~ThiF
Common GO terms GO:0005737 - cytoplasm
GO:0019781 - NEDD8 activating enzyme activity
GO:0043518 - negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045116 - protein neddylation
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 541
Ce

1 430
+ Hs
+ Dm
+ Hs
+ Sc
+ Sc
+ Hs
+ Sc
+ Dm
+ Dm
+ Hs
+ Oc
+ Sc
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024