HitPredict

Interactor 1: CUL1 (Q24311)
Cullin homolog 1 (Lin-19 homolog protein)
Gene: CUL1

Interactor 2: Q7KJ69 (Q7KJ69)
GEO01805p1 (IP02725p) (SKP1-related B) (SKPB)
Gene: SkpB

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~Skp1_POZ
Common GO terms	GO:0005634 - nucleus GO:0016567 - protein ubiquitination GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 774 Dm			1 161
+	Dm
		284976 CUL1_DROME (1-774): 0: 857: 100.00		O77430_DROME (1-161): 1.33e-81: 239: 72.84
+	Mm
		1376703 CUL1_MOUSE (2-774): 0: 828: 61.72		SKP1_MOUSE (1-161): 8.98e-84: 245: 67.49
+	Hs
		928899 CUL1_HUMAN (3-774): 0: 825: 61.68		SKP1_HUMAN (1-161): 1.52e-83: 244: 67.49
+	Hs
		928902 CUL4A_HUMAN (17-774): 0: 774: 29.84		SKP1_HUMAN (1-161): 1.52e-83: 244: 67.49
+	Hs
		928901 CUL3_HUMAN (3-774): 0: 771: 27.45		SKP1_HUMAN (1-161): 1.52e-83: 244: 67.49
+	Hs
		928903 CUL4B_HUMAN (3-774): 0: 756: 29.18		SKP1_HUMAN (1-161): 1.52e-83: 244: 67.49
+	Ce
		105467 CUL1_CAEEL (6-774): 0: 760: 41.92		SKR1_CAEEL (4-160): 1.21e-79: 235: 60.25
+	Hs
		928900 CUL2_HUMAN (7-774): 0: 734: 33.04		SKP1_HUMAN (1-161): 1.52e-83: 244: 67.49
+	Sp
		142922 CUL1_SCHPO (11-774): 0: 754: 39.66		SKP1_SCHPO (1-161): 3.03e-75: 223: 53.37
+	Ce
		106724 CUL1_CAEEL (6-774): 0: 760: 41.92		G5EE67_CAEEL (4-160): 1.28e-68: 206: 49.07
+	Ce
		105999 CUL1_CAEEL (6-774): 0: 760: 41.92		G5EDD8_CAEEL (4-160): 1.7e-66: 201: 50.93
+	Ce
		1088866 CUL1_CAEEL (6-774): 0: 760: 41.92		Q9U1Y9_CAEEL (4-160): 2.82e-63: 193: 46.84
+	At
		221655 CUL1_ARATH (9-774): 0: 734: 27.86		ASK11_ARATH (3-158): 2.52e-71: 213: 46.80
+	Ce
		105582 CUL1_CAEEL (6-774): 0: 760: 41.92		G5ECY4_CAEEL (3-142): 2.91e-53: 168: 35.92
+	Ce
		108000 CUL1_CAEEL (6-774): 0: 760: 41.92		G5EG39_CAEEL (3-142): 2.68e-52: 166: 35.92
+	At
		286197 CUL1_ARATH (9-774): 0: 734: 27.86		ASK14_ARATH (3-158): 1.31e-62: 191: 40.76
+	Ce
		106501 CUL1_CAEEL (6-774): 0: 760: 41.92		G5EDY3_CAEEL (3-141): 1.16e-50: 162: 33.33
+	Ce
		107442 CUL1_CAEEL (6-774): 0: 760: 41.92		G5EFA9_CAEEL (3-142): 2.23e-50: 161: 35.21
+	At
		286162 CUL1_ARATH (9-774): 0: 734: 27.86		ASK16_ARATH (3-158): 6.64e-59: 182: 36.59
+	At
		286251 CUL1_ARATH (9-774): 0: 734: 27.86		ASK19_ARATH (3-157): 9.69e-58: 180: 34.41