HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: INCE (Q9NQS7)
Inner centromere protein
Gene: INCENP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 21346195
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000775 - chromosome, centromeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005721 - pericentric heterochromatin GO:0005819 - spindle
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 183 Hs			1 918
+	Hs
		1097353 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		NIPBL_HUMAN (27-674): 8.6e-60: 225: 14.47
+	Mm
		1223243 CBX5_MOUSE (11-182): 1.22e-55: 175: 59.89		INCE_MOUSE (1-910): 7.32e-68: 245: 66.05
+	Hs
		853302 CBX5_HUMAN (11-182): 1.63e-55: 175: 59.89		NIPBL_HUMAN (27-674): 8.6e-60: 225: 14.47
+	Hs
		1014130 CBX1_HUMAN (36-180): 1.03e-53: 170: 71.33		NIPBL_HUMAN (27-674): 8.6e-60: 225: 14.47
+	Hs
		853416 CBX5_HUMAN (11-182): 1.63e-55: 175: 59.89		INCE_HUMAN (1-918): 1.74e-53: 203: 100.00
+	Hs
		1014210 CBX1_HUMAN (36-180): 1.03e-53: 170: 71.33		INCE_HUMAN (1-918): 1.74e-53: 203: 100.00
+	Hs
		1431832 SUV92_HUMAN (6-156): 4.06e-43: 149: 25.15		SLK_HUMAN (76-821): 3.57e-17: 89.1: 12.09