Protein: SLK
STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)

Gene: SLK
Organism: Homo sapiens
Interactions: 119
UniProt ID: Q9H2G2

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006915 - apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

978294

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1431829

SLK
STE20-like serine/threonine-protein kinase

1

19

Small-scale

0.716

High

126794

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.691

High

214462

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

7

High-throughput

0.691

High

298448

DNJC8
DnaJ homolog subfamily C member 8

1

4

High-throughput

0.691

High

733433

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.691

High

1038354

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

20

High-throughput

0.691

High

1118989

BYST
Bystin

1

2

High-throughput

0.691

High

1158808

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

19

High-throughput

0.691

High

1431841

DAPK2
Death-associated protein kinase 2

1

20

High-throughput

0.691

High

1121525

KEAP1
Kelch-like ECH-associated protein 1

3

6

Small-scale

0.656

High

387892

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

5

High-throughput

0.628

High

1200332

ANR39
Ankyrin repeat domain-containing protein 39

1

17

High-throughput

0.618

High

1328949

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

9

High-throughput

0.618

High

1431836

RBM28
RNA-binding protein 28

1

9

High-throughput

0.618

High

1431838

ZIM2
Zinc finger imprinted 2

1

12

High-throughput

0.618

High

242899

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

247426

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

15

High-throughput

0.618

High

317300

STK10
Serine/threonine-protein kinase 10

1

18

High-throughput

0.618

High

412593

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

466452

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

831411

CCNF
Cyclin-F

1

5

High-throughput

0.618

High

962466

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

1108143

SQSTM
Sequestosome-1

1

11

High-throughput

0.618

High

1122553

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

20

High-throughput

0.618

High

1255499

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1431831

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

537894

HSP7C
Heat shock cognate 71 kDa protein

2

20

High-throughput

0.611

High

862447

YAP1
Transcriptional coactivator YAP1

2

20

High-throughput

0.611

High

709011

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

801522

HSPA9
Stress-70 protein, mitochondrial

2

20

High-throughput

0.601

High

346315

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

12

High-throughput

0.584

High

1332800

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.578

High

1209644

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

17

High-throughput

0.575

High

1315713

DND1
Dead end protein homolog 1

1

14

High-throughput

0.575

High

1431833

RAB18
Ras-related protein Rab-18

1

14

High-throughput

0.575

High

1358198

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

2

High-throughput

0.574

High

134864

SAP18
Histone deacetylase complex subunit SAP18

1

1

High-throughput

0.536

High

347318

BAG2
BAG family molecular chaperone regulator 2

1

6

High-throughput

0.536

High

721065

CLIP1
CAP-Gly domain-containing linker protein 1

1

20

High-throughput

0.536

High

925976

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

High-throughput

0.536

High

931106

HSP72
Heat shock-related 70 kDa protein 2

1

20

High-throughput

0.536

High

1118331

EXOS2
Exosome complex component RRP4

1

2

High-throughput

0.536

High

1273127

MOB1B
MOB kinase activator 1B

1

18

High-throughput

0.536

High

1339341

BBS1
BBSome complex member BBS1

1

4

High-throughput

0.536

High

1371962

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

1

High-throughput

0.536

High

1392236

DDX27
Probable ATP-dependent RNA helicase DDX27

1

19

High-throughput

0.536

High

1404391

CDC5L
Cell division cycle 5-like protein

1

13

High-throughput

0.536

High

1431830

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

14

High-throughput

0.536

High

1431842

RUVB2
RuvB-like 2

1

6

High-throughput

0.536

High

1431843

RUVB1
RuvB-like 1

1

6

High-throughput

0.536

High

1212240

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

20

Small-scale

0.527

High

348730

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.515

High

226996

ENSA
Alpha-endosulfine

1

0

High-throughput

0.513

High

568699

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.513

High

725805

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.513

High

863429

GLYG
Glycogenin-1

1

0

High-throughput

0.513

High

1431844

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

630358

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

2

High-throughput

0.489

High

665708

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

1

High-throughput

0.489

High

1254236

TBCD9
TBC1 domain family member 9

1

5

High-throughput

0.489

High

1280222

MILR1
Allergin-1

1

10

High-throughput

0.489

High

1336569

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

10

High-throughput

0.489

High

1389113

KBP
KIF-binding protein

1

2

High-throughput

0.489

High

1390562

BORC8
BLOC-1-related complex subunit 8

1

1

High-throughput

0.489

High

1430017

NSRP1
Nuclear speckle splicing regulatory protein 1

1

3

High-throughput

0.489

High

1431832

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

6

High-throughput

0.489

High

1431835

MED17
Mediator of RNA polymerase II transcription subunit 17

1

3

High-throughput

0.489

High

176748

MCF2L
Guanine nucleotide exchange factor DBS

1

19

High-throughput

0.479

High

556336

CADH1
Cadherin-1

1

9

High-throughput

0.479

High

613458

VINC
Vinculin

1

20

High-throughput

0.479

High

691423

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

961840

RL37A
Large ribosomal subunit protein eL43

1

2

High-throughput

0.479

High

971066

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

12

High-throughput

0.479

High

986204

RL8
Large ribosomal subunit protein uL2

1

2

High-throughput

0.479

High

1067709

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

1094623

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

4

High-throughput

0.479

High

1103893

MYO7A
Unconventional myosin-VIIa

1

20

High-throughput

0.479

High

1132969

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

11

High-throughput

0.479

High

1138623

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1143263

PLEC
Plectin

1

20

High-throughput

0.479

High

1208064

CYTSB
Cytospin-B

1

20

High-throughput

0.479

High

1246982

RICTR
Rapamycin-insensitive companion of mTOR

1

5

High-throughput

0.479

High

1289618

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1352366

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.479

High

1363844

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

5

High-throughput

0.479

High

1364588

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1370368

CSN5
COP9 signalosome complex subunit 5

1

9

High-throughput

0.479

High

1414563

DDX23
Probable ATP-dependent RNA helicase DDX23

1

20

High-throughput

0.479

High

1428965

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1431837

ARGL1
Arginine and glutamate-rich protein 1

1

11

High-throughput

0.479

High

1431839

ZRAN1
Ubiquitin thioesterase ZRANB1

1

18

High-throughput

0.479

High

1431846

TRI17
E3 ubiquitin-protein ligase TRIM17

1

13

Small-scale

0.479

High

324043

CSTN1
Calsyntenin-1

1

12

Small-scale

0.464

High

281784

VP26A
Vacuolar protein sorting-associated protein 26A

1

0

High-throughput

0.458

High

662276

PAX7
Paired box protein Pax-7

1

7

High-throughput

0.457

High

851667

GATA4
Transcription factor GATA-4

1

3

High-throughput

0.457

High

261275

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.445

High

328151

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

18

High-throughput

0.445

High

552078

ADT1
ADP/ATP translocase 1

1

6

High-throughput

0.437

High

589660

RFA2
Replication protein A 32 kDa subunit

1

12

High-throughput

0.437

High

696478

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.437

High

769148

RFA3
Replication protein A 14 kDa subunit

1

9

High-throughput

0.437

High

1226523

DCA15
DDB1- and CUL4-associated factor 15

1

1

High-throughput

0.437

High

1245128

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.437

High

1276775

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

11

High-throughput

0.437

High

1431840

Z3H7B
Zinc finger CCCH domain-containing protein 7B

1

20

High-throughput

0.437

High

1431845

DMXL1
DmX-like protein 1

1

10

High-throughput

0.437

High

62595

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

330311

VENTX
Homeobox protein VENTX

1

9

High-throughput

0.407

High

1104093

RM49
Large ribosomal subunit protein mL49

1

2

High-throughput

0.407

High

1395404

NEUL4
Neuralized-like protein 4

1

3

High-throughput

0.407

High

1420712

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.407

High

1331683

RM43
Large ribosomal subunit protein mL43

3

0

High-throughput

0.347

High

1395646

CH076
Uncharacterized protein C8orf76

1

0

High-throughput

0.279

Low

1431834

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.249

Low

1155100

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

1403423

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025