HitPredict

Interactor 1: PTK7 (Q13308)
Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)
Gene: PTK7

Interactor 2: CAC1C (Q13936)
Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)
Gene: CACNA1C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	35575683, 37207277
Identification Methods	cross-linking study, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1070 Hs			1 2221
+	Hs
		1119313 ROBO2_HUMAN (1-810): 9.04e-106: 363: 15.91		CAC1C_HUMAN (1-2221): 0: 1897: 100.00
+	Hs
		1119362 ALK_HUMAN (695-1067): 1.22e-52: 204: 32.90		CAC1C_HUMAN (1-2221): 0: 1897: 100.00
+	Hs
		1119149 NTRK2_HUMAN (137-313): 1.03e-17: 90.9: 18.99		CAC1C_HUMAN (1-2221): 0: 1897: 100.00
+	Hs
		1119146 NTRK3_HUMAN (40-228): 3.85e-16: 85.5: 19.10		CAC1C_HUMAN (1-2221): 0: 1897: 100.00
+	Hs
		1119226 TITIN_HUMAN (599-828): 3.2e-10: 67: 15.25		CAC1C_HUMAN (1-2221): 0: 1897: 100.00
+	Mm
		591448 FGFR1_MOUSE (2-231): 1.04e-34: 145: 12.77		CAC1C_MOUSE (1-2221): 0: 1781: 91.00
+	Mm
		1032694 SPEG_MOUSE (591-700): 8.79e-09: 62: 23.64		CAC1C_MOUSE (1-2221): 0: 1781: 91.00
+	Hs
		1159528 NTRK2_HUMAN (137-313): 1.03e-17: 90.9: 18.99		SCN2A_HUMAN (1221-1551): 1.04e-16: 89.6: 16.33
+	Hs
		139699 PGBM_HUMAN (591-717): 3.59e-10: 66.6: 19.53		CAC1A_HUMAN (1520-1966): 4.68e-14: 80.8: 9.81