Protein: SCN2A
Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2)

Gene: SCN2A
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q99250

Gene Ontology (top 5):
GO:0001518 - voltage-gated sodium channel complex
GO:0005248 - voltage-gated sodium channel activity
GO:0005516 - calmodulin binding
GO:0005886 - plasma membrane
GO:0006814 - sodium ion transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1155139

SCN9A
Sodium channel protein type 9 subunit alpha

1

5

High-throughput

0.691

High

1403983

SCN3A
Sodium channel protein type 3 subunit alpha

1

5

High-throughput

0.691

High

680470

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

2

2

High-throughput

0.601

High

1403979

DNJC5
DnaJ homolog subfamily C member 5

2

3

High-throughput

0.584

High

255181

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.575

High

1119268

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

5

High-throughput

0.575

High

298783

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

2

2

High-throughput

0.549

High

378777

LV147
Immunoglobulin lambda variable 1-47

1

0

High-throughput

0.546

High

135321

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

12

High-throughput

0.536

High

420834

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

5

High-throughput

0.536

High

460617

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

1

High-throughput

0.536

High

466590

TNR16
Tumor necrosis factor receptor superfamily member 16

1

2

High-throughput

0.536

High

482632

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

11

High-throughput

0.536

High

550427

PABP1
Polyadenylate-binding protein 1

1

9

High-throughput

0.536

High

565535

RARG
Retinoic acid receptor gamma

1

3

High-throughput

0.536

High

565689

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

7

High-throughput

0.536

High

627400

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

9

High-throughput

0.536

High

686643

ELAV4
ELAV-like protein 4

1

15

High-throughput

0.536

High

690356

STOM
Stomatin

1

3

High-throughput

0.536

High

834511

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

900471

FXR2
RNA-binding protein FXR2

1

3

High-throughput

0.536

High

931885

EPHA5
Ephrin type-A receptor 5

1

10

High-throughput

0.536

High

989865

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

11

High-throughput

0.536

High

994740

YBOX1
Y-box-binding protein 1

1

1

High-throughput

0.536

High

1089818

ILF3
Interleukin enhancer-binding factor 3

1

6

High-throughput

0.536

High

1102744

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

8

High-throughput

0.536

High

1128575

ELAV3
ELAV-like protein 3

1

13

High-throughput

0.536

High

1159528

NTRK2
BDNF/NT-3 growth factors receptor

1

9

High-throughput

0.536

High

1335374

CAMKV
CaM kinase-like vesicle-associated protein

1

9

High-throughput

0.536

High

1370526

FGF13
Fibroblast growth factor 13

1

7

High-throughput

0.536

High

1403975

SYT11
Synaptotagmin-11

1

12

High-throughput

0.536

High

1403981

PLXA4
Plexin-A4

1

5

High-throughput

0.536

High

1403982

ITM2C
Integral membrane protein 2C

1

3

High-throughput

0.536

High

1403984

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

8

High-throughput

0.536

High

1403986

S53A1
Solute carrier family 53 member 1

1

1

High-throughput

0.536

High

1403988

KDIS
Kinase D-interacting substrate of 220 kDa

1

7

High-throughput

0.536

High

1403989

PCDGG
Protocadherin gamma-B4

1

20

High-throughput

0.536

High

1403992

PCDGI
Protocadherin gamma-B6

1

20

High-throughput

0.536

High

1403993

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

10

High-throughput

0.536

High

987454

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.513

High

1026190

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.513

High

1067174

ABCC8
ATP-binding cassette sub-family C member 8

1

0

High-throughput

0.513

High

1139669

SYK
Lysine--tRNA ligase

1

0

High-throughput

0.513

High

1366528

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.513

High

1386484

CC124
Coiled-coil domain-containing protein 124

1

0

High-throughput

0.513

High

1403985

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.513

High

86025

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

7

High-throughput

0.489

High

522480

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.489

High

1090283

ELAV2
ELAV-like protein 2

1

14

High-throughput

0.489

High

1102067

PABP4
Polyadenylate-binding protein 4

1

9

High-throughput

0.489

High

1152032

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

10

High-throughput

0.489

High

1208950

DCA10
DDB1- and CUL4-associated factor 10

1

4

High-throughput

0.489

High

1403978

PABP3
Polyadenylate-binding protein 3

1

9

High-throughput

0.489

High

1403991

DJC16
DnaJ homolog subfamily C member 16

1

5

High-throughput

0.489

High

1403994

FCGBP
IgGFc-binding protein

1

2

High-throughput

0.489

High

1312046

DJC10
DnaJ homolog subfamily C member 10

1

3

High-throughput

0.479

High

1403974

SH3G2
Endophilin-A1

1

0

High-throughput

0.458

High

1103520

MPP3
MAGUK p55 subfamily member 3

1

3

High-throughput

0.457

High

1294241

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.457

High

1227321

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.445

High

1155690

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

1403980

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

2

High-throughput

0.417

High

532028

PF4V
Platelet factor 4 variant

1

0

High-throughput

0.279

Low

984653

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.279

Low

1036276

CP27A
Sterol 26-hydroxylase, mitochondrial

1

0

High-throughput

0.279

Low

1403976

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.279

Low

1403977

RM46
Large ribosomal subunit protein mL46

1

0

High-throughput

0.279

Low

1403987

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

High-throughput

0.279

Low

1403990

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.279

Low

106519

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

567466

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025