HitPredict

Interactor 1: LRFN1 (Q2WF71)
Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) (Synaptic differentiation-enhancing molecule 1)
Gene: LRFN1

Interactor 2: DLG4 (Q62108)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.825

Property	Details
Experiments	28671696, 16828986
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PDZ~fn3
Common GO terms	GO:0098839 - postsynaptic density membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 766 Mm			1 724
+	Mm
		1103493 LRFN1_MOUSE (1-766): 4.33e-139: 430: 100.00		DLG1_MOUSE (8-724): 0: 577: 68.93
+	Mm
		471547 LRC4B_MOUSE (5-150): 2.05e-24: 111: 19.30		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		1143410 LRC4C_MOUSE (2-367): 8.66e-22: 102: 13.83		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		524114 CNTN1_MOUSE (215-644): 1.68e-14: 79.7: 13.26		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Rn
		677783 LRFN2_RAT (5-109): 2.08e-14: 79.3: 14.82		DLG4_RAT (1-724): 0: 671: 99.45
+	Mm
		1143368 LRFN2_MOUSE (5-109): 2.88e-14: 78.9: 14.82		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		1143377 LRFN4_MOUSE (678-759): 9.55e-10: 63.9: 11.24		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		936185 LRC4C_MOUSE (2-367): 8.66e-22: 102: 13.83		DLG3_MOUSE (20-724): 0: 585: 63.94
+	Rn
		1115172 LRFN2_RAT (5-109): 2.08e-14: 79.3: 14.82		DLG3_RAT (20-724): 0: 585: 63.94
+	Mm
		936183 LRFN2_MOUSE (5-109): 2.88e-14: 78.9: 14.82		DLG3_MOUSE (20-724): 0: 585: 63.94
+	Mm
		1193431 LRFN2_MOUSE (5-109): 2.88e-14: 78.9: 14.82		DLG1_MOUSE (8-724): 0: 577: 68.93
+	Rn
		1115171 LRFN2_RAT (5-109): 2.08e-14: 79.3: 14.82		DLG1_RAT (8-724): 0: 564: 66.98
+	Hs
		1050029 LRIG1_HUMAN (105-765): 9.45e-29: 125: 10.32		SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72
+	Mm
		1207544 LRC4C_MOUSE (2-367): 8.66e-22: 102: 13.83		DLG2_MOUSE (234-473): 4.91e-17: 87.8: 21.95
+	Hs
		1162226 LRFN4_HUMAN (678-759): 7.37e-10: 64.3: 10.11		PALS1_HUMAN (22-196): 1.91e-13: 75.9: 14.21