Protein: DPTOR
DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6)

Gene: DPTOR, DEPTOR
Organism: Homo sapiens
Interactions: 81
UniProt ID: Q8TB45

Gene Ontology (top 5):
GO:0004860 - protein kinase inhibitor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

839325

MTOR
Serine/threonine-protein kinase mTOR

5

2

Small-scale

0.935

High

1348009

FBW1A
F-box/WD repeat-containing protein 1A

6

4

Small-scale

0.858

High

1322596

RPTOR
Regulatory-associated protein of mTOR

2

4

Small-scale

0.802

High

1348003

FBW1B
F-box/WD repeat-containing protein 11

4

4

Small-scale

0.781

High

1347997

LST8
Target of rapamycin complex subunit LST8

2

1

Small-scale

0.737

High

1093886

TRAF1
TNF receptor-associated factor 1

1

1

High-throughput

0.573

High

1246887

RICTR
Rapamycin-insensitive companion of mTOR

1

1

Small-scale

0.554

High

1215330

DCAF8
DDB1- and CUL4-associated factor 8

1

3

Small-scale

0.553

High

1347992

FBXW7
F-box/WD repeat-containing protein 7

1

4

Small-scale

0.553

High

639271

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

1

Small-scale

0.523

High

422674

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

658613

KS6B1
Ribosomal protein S6 kinase beta-1

1

5

Small-scale

0.501

High

1148363

KS6A1
Ribosomal protein S6 kinase alpha-1

1

3

Small-scale

0.501

High

691800

MK03
Mitogen-activated protein kinase 3

1

0

Small-scale

0.480

High

334352

TRI16
Tripartite motif-containing protein 16

1

1

Small-scale

0.479

High

374083

RASN
GTPase NRas

1

3

High-throughput

0.479

High

568829

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

1

Small-scale

0.479

High

605755

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

4

Small-scale

0.479

High

889310

NUMB
Protein numb homolog

1

1

Small-scale

0.479

High

1050488

UBE3A
Ubiquitin-protein ligase E3A

1

1

Small-scale

0.479

High

1112613

CUL1
Cullin-1

1

3

Small-scale

0.479

High

1113770

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1309536

MAPK5
MAP kinase-activated protein kinase 5

1

1

Small-scale

0.479

High

1347990

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

Small-scale

0.479

High

1348012

X5D778
Ankyrin repeat domain 11 isoform A

1

4

High-throughput

0.470

High

960496

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.464

High

123777

MYO1C
Unconventional myosin-Ic

1

0

Small-scale

0.458

High

245501

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

Small-scale

0.458

High

287976

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

0

Small-scale

0.458

High

390687

TFR1
Transferrin receptor protein 1

1

0

Small-scale

0.458

High

410953

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

0

Small-scale

0.458

High

612267

ARF4
ADP-ribosylation factor 4

1

0

Small-scale

0.458

High

834212

CSK
Tyrosine-protein kinase CSK

1

0

Small-scale

0.458

High

1022826

RHG04
Rho GTPase-activating protein 4

1

0

Small-scale

0.458

High

1107947

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

1347998

EI2BG
Translation initiation factor eIF2B subunit gamma

1

0

Small-scale

0.458

High

1348000

PIM2
Serine/threonine-protein kinase pim-2

1

0

Small-scale

0.458

High

1348002

AKA11
A-kinase anchor protein 11

1

0

Small-scale

0.458

High

1347991

CUL5
Cullin-5

1

3

Small-scale

0.457

High

1247955

ANR11
Ankyrin repeat domain-containing protein 11

1

4

High-throughput

0.439

High

123148

DX39A
ATP-dependent RNA helicase DDX39A

1

1

Small-scale

0.437

High

173110

XPO1
Exportin-1

1

2

High-throughput

0.437

High

325941

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

Small-scale

0.437

High

543242

UBL4A
Ubiquitin-like protein 4A

1

2

Small-scale

0.437

High

856822

BAG6
Large proline-rich protein BAG6

1

2

Small-scale

0.437

High

887571

PSB3
Proteasome subunit beta type-3

1

2

Small-scale

0.437

High

974331

LSM6
U6 snRNA-associated Sm-like protein LSm6

1

2

Small-scale

0.437

High

977547

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

2

Small-scale

0.437

High

1054617

PSME1
Proteasome activator complex subunit 1

1

1

Small-scale

0.437

High

1121470

KEAP1
Kelch-like ECH-associated protein 1

1

1

Small-scale

0.437

High

1156554

CCDC6
Coiled-coil domain-containing protein 6

1

1

Small-scale

0.437

High

1275573

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

Small-scale

0.437

High

1347993

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

Small-scale

0.437

High

1347995

ATX2
Ataxin-2

1

2

Small-scale

0.437

High

1348007

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

1

Small-scale

0.437

High

1348008

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

1

Small-scale

0.437

High

1348010

COPG1
Coatomer subunit gamma-1

1

1

Small-scale

0.437

High

1199607

KLH22
Kelch-like protein 22

1

1

High-throughput

0.407

High

1347987

CC110
Coiled-coil domain-containing protein 110

1

0

High-throughput

0.299

High

776922

CHKA
Choline kinase alpha

1

0

Small-scale

0.261

Low

1347986

LNX1
E3 ubiquitin-protein ligase LNX

1

0

Small-scale

0.261

Low

1347988

FBX25
F-box only protein 25

1

0

Small-scale

0.261

Low

1347989

TRI41
E3 ubiquitin-protein ligase TRIM41

1

0

High-throughput

0.251

Low

122818

KIF2A
Kinesin-like protein KIF2A

1

0

Small-scale

0.249

Low

144457

SCD
Stearoyl-CoA desaturase

1

0

Small-scale

0.249

Low

328316

NDUB4
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

1

0

Small-scale

0.249

Low

483609

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

Small-scale

0.249

Low

728804

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

Small-scale

0.249

Low

868742

LEG7
Galectin-7

1

0

Small-scale

0.249

Low

1086644

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

Small-scale

0.249

Low

1117005

LAMB3
Laminin subunit beta-3

1

0

Small-scale

0.249

Low

1164479

MIC60
MICOS complex subunit MIC60

1

0

Small-scale

0.249

Low

1219857

OBI1
ORC ubiquitin ligase 1

1

0

Small-scale

0.249

Low

1347994

OTUB1
Ubiquitin thioesterase OTUB1

1

0

Small-scale

0.249

Low

1347996

RN126
E3 ubiquitin-protein ligase RNF126

1

0

Small-scale

0.249

Low

1347999

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

0

Small-scale

0.249

Low

1348001

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

Small-scale

0.249

Low

1348004

AGO2
Protein argonaute-2

1

0

Small-scale

0.249

Low

1348005

SYNRG
Synergin gamma

1

0

Small-scale

0.249

Low

1348006

MAGD2
Melanoma-associated antigen D2

1

0

Small-scale

0.249

Low

1348011

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025