HitPredict

Interactor 1: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Interactor 2: Q9H4D1 (Q9H4D1)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3)
Gene: dik

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.80	0.668

Property	Details
Experiments	21931591
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BIR~Pkinase
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 618 Hs			1 784
+	Hs
		943935 BIRC2_HUMAN (1-618): 0: 701: 100.00		RIPK4_HUMAN (1-784): 0: 692: 93.99
+	Hs
		1295554 MIB1_HUMAN (231-616): 1.72e-51: 193: 15.83		Q9H4D1_HUMAN (1-784): 0: 711: 100.00
+	Hs
		1107208 BIRC3_HUMAN (5-259): 3.43e-52: 190: 28.03		Q9H4D1_HUMAN (1-784): 0: 711: 100.00
+	Hs
		214424 BIRC2_HUMAN (1-618): 0: 701: 100.00		RIPK2_HUMAN (31-284): 2.19e-54: 198: 44.36
+	Hs
		943984 MIB1_HUMAN (231-616): 1.72e-51: 193: 15.83		RIPK4_HUMAN (1-784): 0: 692: 93.99
+	Hs
		943934 BIRC3_HUMAN (5-259): 3.43e-52: 190: 28.03		RIPK4_HUMAN (1-784): 0: 692: 93.99
+	Hs
		1107515 BIRC2_HUMAN (1-618): 0: 701: 100.00		RIPK3_HUMAN (21-286): 1.6e-35: 143: 35.74
+	Hs
		1022793 XIAP_HUMAN (17-167): 7.75e-31: 128: 29.87		Q9H4D1_HUMAN (1-784): 0: 711: 100.00
+	Hs
		943911 XIAP_HUMAN (17-167): 7.75e-31: 128: 29.87		RIPK4_HUMAN (1-784): 0: 692: 93.99
+	Mm
		1281840 MIB1_MOUSE (231-616): 1.25e-52: 196: 15.83		DAPK1_MOUSE (465-783): 1.04e-80: 284: 25.47
+	Hs
		920472 MIB1_HUMAN (231-616): 1.72e-51: 193: 15.83		DAPK1_HUMAN (465-783): 2.45e-81: 286: 25.47
+	Hs
		920428 MDM2_HUMAN (344-617): 7.81e-34: 137: 15.56		DAPK1_HUMAN (465-783): 2.45e-81: 286: 25.47
+	Hs
		214423 BIRC3_HUMAN (5-259): 3.43e-52: 190: 28.03		RIPK2_HUMAN (31-284): 2.19e-54: 198: 44.36
+	Hs
		1107376 BIRC3_HUMAN (5-259): 3.43e-52: 190: 28.03		RIPK3_HUMAN (21-286): 1.6e-35: 143: 35.74
+	Hs
		214414 XIAP_HUMAN (17-167): 7.75e-31: 128: 29.87		RIPK2_HUMAN (31-284): 2.19e-54: 198: 44.36
+	Hs
		274135 MDM2_HUMAN (344-617): 7.81e-34: 137: 15.56		ANR17_HUMAN (629-784): 2.35e-39: 160: 30.19
+	Hs
		1022818 XIAP_HUMAN (17-167): 7.75e-31: 128: 29.87		RIPK3_HUMAN (21-286): 1.6e-35: 143: 35.74
+	Dm
		1173356 DIAP2_DROME (261-462): 4.26e-12: 70.8: 16.99		ANKHM_DROME (319-626): 1.36e-51: 198: 21.54
+	Zm
		36768 C0HHU5_MAIZE (435-618): 7.48e-32: 128: 15.18		A0A1D6M3A7_MAIZE (602-784): 2.95e-25: 114: 20.20