HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62)
Gene: SQSTM1

Interactor 2: MLP3C (Q9BXW4)
Microtubule-associated protein 1 light chain 3 gamma (Autophagy-related protein LC3 C) (Autophagy-related ubiquitin-like modifier LC3 C) (MAP1 light chain 3-like protein 3) (Microtubule-associated proteins 1A/1B light chain 3C) (MAP1A/MAP1B LC3 C) (MAP1A/MAP1B light chain 3 C)
Gene: MAP1LC3C

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.757

Property	Details
Experiments	29426817, 31006538, 34929165, 29149599, 37219487, 37658135, 31286822, 19250911, 23022382, 33436498, 24668264, 20562859, 34799561
Identification Methods	pull down, affinity chromatography technology, unspecified method, proximity labelling technology, fluorescence polarization spectroscopy, anti tag coimmunoprecipitation, phage display
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000423 - mitophagy GO:0005776 - autophagosome GO:0005829 - cytosol GO:0016236 - macroautophagy GO:0031625 - ubiquitin protein ligase binding and 1 others more... GO:0035973 - aggrephagy
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 440 Hs			1 147
+	Hs
		1107826 SQSTM_HUMAN (1-440): 0: 760: 100.00		Q6IAW1_HUMAN (13-127): 3.46e-54: 168: 38.26
+	Hs
		327992 SQSTM_HUMAN (1-440): 0: 760: 100.00		GBRAP_HUMAN (13-127): 3.46e-54: 168: 38.26
+	Hs
		952151 SQSTM_HUMAN (1-440): 0: 760: 100.00		GBRL2_HUMAN (13-126): 1.66e-54: 168: 42.98
+	Hs
		1108148 SQSTM_HUMAN (1-440): 0: 760: 100.00		MLP3A_HUMAN (7-126): 2.5e-53: 165: 59.17
+	Hs
		1108127 SQSTM_HUMAN (1-440): 0: 760: 100.00		MLP3B_HUMAN (7-127): 8.19e-53: 164: 54.55
+	Hs
		1108137 SQSTM_HUMAN (1-440): 0: 760: 100.00		GBRL1_HUMAN (13-126): 4.78e-52: 162: 39.47
+	Hs
		64572 SQSTM_HUMAN (1-440): 0: 760: 100.00		MP3B2_HUMAN (7-127): 1.02e-51: 162: 53.72
+	Mm
		1225669 SQSTM_MOUSE (1-440): 0: 731: 90.72		MLP3A_MOUSE (7-126): 2.5e-53: 165: 59.17
+	Mm
		1225673 SQSTM_MOUSE (1-440): 0: 731: 90.72		MLP3B_MOUSE (7-126): 6.51e-53: 165: 55.00
+	Hs
		328063 MIB1_HUMAN (105-233): 3.49e-43: 164: 25.19		GBRAP_HUMAN (13-127): 3.46e-54: 168: 38.26
+	Ce
		98545 F1LIM5_CAEEL (79-220): 6.61e-30: 124: 22.70		LGG1_CAEEL (12-126): 1.47e-52: 164: 38.26
+	Hs
		1128820 NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78		MLP3C_HUMAN (1-147): 4.66e-72: 214: 100.00
+	Ce
		98550 F1LIM5_CAEEL (79-220): 6.61e-30: 124: 22.70		LGG2_CAEEL (10-126): 1.89e-44: 143: 47.01
+	Dm
		571081 REF2P_DROME (107-170): 7.38e-20: 94: 36.92		Q9W2S2_DROME (13-127): 6.16e-55: 170: 37.39
+	Hs
		343046 HERC2_HUMAN (120-197): 2.61e-12: 71.3: 32.50		MLP3B_HUMAN (7-127): 8.19e-53: 164: 54.55
+	Hs
		328011 NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78		GBRAP_HUMAN (13-127): 3.46e-54: 168: 38.26
+	Hs
		952169 NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78		GBRL2_HUMAN (13-126): 1.66e-54: 168: 42.98
+	Hs
		1128829 NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78		MLP3A_HUMAN (7-126): 2.5e-53: 165: 59.17
+	Hs
		1128823 NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78		MLP3B_HUMAN (7-127): 8.19e-53: 164: 54.55
+	Hs
		1128826 NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78		GBRL1_HUMAN (13-126): 4.78e-52: 162: 39.47