HitPredict

Interactor 1: MP3B2 (A6NCE7)
Microtubule-associated protein 1 light chain 3 beta 2 (Microtubule-associated proteins 1A/1B light chain 3 beta 2) (Microtubule-associated proteins 1A/1B light chain 3B-like) (MAP1A/MAP1B LC3 B-like) (MAP1A/MAP1B light chain 3 B-like)
Gene: MAP1LC3B2

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62)
Gene: SQSTM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34037656
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000423 - mitophagy GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 125 Hs			1 440
+	Hs
		1108127 MLP3B_HUMAN (1-125): 7.05e-57: 174: 99.20		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1108148 MLP3A_HUMAN (1-120): 8.52e-55: 168: 81.67		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		952151 GBRL2_HUMAN (7-120): 4.2e-53: 164: 38.60		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1107826 Q6IAW1_HUMAN (7-121): 1.18e-52: 163: 30.44		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		327992 GBRAP_HUMAN (7-121): 1.18e-52: 163: 30.44		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1108111 MLP3C_HUMAN (1-120): 3.24e-51: 160: 54.17		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1108137 GBRL1_HUMAN (7-120): 2.7e-51: 159: 31.58		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Mm
		1225673 MLP3B_MOUSE (1-125): 8.4e-56: 171: 94.40		SQSTM_MOUSE (1-440): 0: 731: 90.72
+	Mm
		1225669 MLP3A_MOUSE (1-120): 8.52e-55: 168: 81.67		SQSTM_MOUSE (1-440): 0: 731: 90.72
+	Hs
		328063 GBRAP_HUMAN (7-121): 1.18e-52: 163: 30.44		MIB1_HUMAN (105-233): 3.49e-43: 164: 25.19
+	Ce
		98545 LGG1_CAEEL (6-120): 1.02e-50: 158: 32.17		F1LIM5_CAEEL (79-220): 6.61e-30: 124: 22.70
+	Ce
		98550 LGG2_CAEEL (6-120): 8.93e-45: 143: 57.39		F1LIM5_CAEEL (79-220): 6.61e-30: 124: 22.70
+	Dm
		571081 Q9W2S2_DROME (7-122): 1.04e-53: 166: 30.17		REF2P_DROME (107-170): 7.38e-20: 94: 36.92
+	Hs
		343046 MLP3B_HUMAN (1-125): 7.05e-57: 174: 99.20		HERC2_HUMAN (120-197): 2.61e-12: 71.3: 32.50
+	Hs
		1128823 MLP3B_HUMAN (1-125): 7.05e-57: 174: 99.20		NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78
+	Hs
		1128829 MLP3A_HUMAN (1-120): 8.52e-55: 168: 81.67		NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78
+	Hs
		952169 GBRL2_HUMAN (7-120): 4.2e-53: 164: 38.60		NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78
+	Hs
		328011 GBRAP_HUMAN (7-121): 1.18e-52: 163: 30.44		NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78
+	Hs
		1128820 MLP3C_HUMAN (1-120): 3.24e-51: 160: 54.17		NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78
+	Hs
		1128826 GBRL1_HUMAN (7-120): 2.7e-51: 159: 31.58		NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78