HitPredict

Interactor 1: PCGF3 (Q3KNV8)
Polycomb group RING finger protein 3 (RING finger protein 3A)
Gene: PCGF3

Interactor 2: PCGF1 (Q9BSM1)
Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)
Gene: PCGF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RAWUL~RAWUL, zf-C3HC4_2~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 242 Hs			1 259
+	Hs
		718150 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		PCGF1_HUMAN (1-259): 4.13e-82: 248: 100.00
+	Hs
		717887 PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		717488 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		718402 PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00		PCGF2_HUMAN (30-255): 4.65e-59: 192: 35.57
+	Hs
		1108506 PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00		PCGF3_HUMAN (32-257): 1.89e-56: 182: 38.68
+	Hs
		717489 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		PCGF2_HUMAN (30-255): 4.65e-59: 192: 35.57
+	Hs
		1108538 PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00		PCGF6_HUMAN (26-252): 6.21e-45: 156: 36.05
+	Hs
		1108511 PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00		PCGF5_HUMAN (30-257): 3.38e-44: 151: 29.41
+	Hs
		718164 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		PCGF6_HUMAN (26-252): 6.21e-45: 156: 36.05
+	Hs
		1108533 PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		717977 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		PCGF5_HUMAN (30-257): 3.38e-44: 151: 29.41
+	Mm
		1207257 PCGF3_MOUSE (1-242): 1.74e-64: 202: 97.52		RING2_MOUSE (24-259): 5.08e-39: 140: 16.88
+	Hs
		718129 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Dr
		1186371 BMI1B_DANRE (3-238): 4.71e-61: 196: 31.36		RING2_DANRE (24-259): 5.59e-38: 137: 16.56
+	Dr
		1193368 BMI1A_DANRE (3-238): 5.06e-60: 193: 33.05		RING2_DANRE (24-259): 5.59e-38: 137: 16.56
+	Hs
		987977 PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59
+	Hs
		717765 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		TRI26_HUMAN (32-223): 6.79e-32: 124: 19.90
+	Hs
		717742 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59
+	Hs
		988039 R4GMX3_HUMAN (3-238): 7.96e-59: 194: 33.76		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59