HitPredict

Interactor 1: PCGF3 (Q3KNV8)
Polycomb group RING finger protein 3 (RING finger protein 3A)
Gene: PCGF3

Interactor 2: CBX8 (Q9HC52)
Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)
Gene: CBX8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.883

Property	Details
Experiments	27705803, 24981860, 21282530
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 242 Hs			1 389
+	Hs
		718213 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		CBX8_HUMAN (1-389): 5.01e-104: 314: 100.00
+	Mm
		639481 BMI1_MOUSE (3-238): 5e-59: 191: 33.48		CBX8_MOUSE (1-389): 2.38e-101: 306: 84.58
+	Hs
		316045 PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00		CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26
+	Hs
		123257 PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00		CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93
+	Hs
		315976 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26
+	Hs
		315977 PCGF2_HUMAN (3-238): 5.76e-59: 191: 34.03		CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26
+	Hs
		123193 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93
+	Hs
		123194 PCGF2_HUMAN (3-238): 5.76e-59: 191: 34.03		CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93
+	Hs
		718131 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		MPP8_HUMAN (6-356): 2.27e-52: 188: 18.85
+	Hs
		1059156 PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00		CBX2_HUMAN (2-348): 3.75e-46: 167: 22.03
+	Dr
		1186372 BMI1B_DANRE (3-238): 4.71e-61: 196: 31.36		Q804D1_DANRE (1-249): 1.15e-47: 170: 26.91
+	Dr
		1193374 BMI1A_DANRE (3-238): 5.06e-60: 193: 33.05		Q804D1_DANRE (1-249): 1.15e-47: 170: 26.91
+	Hs
		717831 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		CBX2_HUMAN (2-348): 3.75e-46: 167: 22.03
+	Mm
		639466 BMI1_MOUSE (3-238): 5e-59: 191: 33.48		CBX2_MOUSE (2-335): 3.31e-46: 167: 21.11
+	Hs
		327845 PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00		CBX7_HUMAN (1-235): 2.71e-41: 147: 28.46
+	Hs
		327830 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		CBX7_HUMAN (1-235): 2.71e-41: 147: 28.46
+	Hs
		327831 PCGF2_HUMAN (3-238): 5.76e-59: 191: 34.03		CBX7_HUMAN (1-235): 2.71e-41: 147: 28.46
+	Hs
		1027025 PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00		CBX3_HUMAN (9-144): 1.3e-26: 106: 25.74
+	Hs
		717776 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		CBX3_HUMAN (9-144): 1.3e-26: 106: 25.74
+	Hs
		717529 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		CBX5_HUMAN (11-144): 1.06e-25: 104: 25.00