Protein: Q94533
Ribosomal protein S6 kinase (EC 2.7.11.1)

Gene: Q94533, S6k
Organism: Drosophila melanogaster
Interactions: 72
UniProt ID: Q94533

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004711 - ribosomal protein S6 kinase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1173173

CDC37
Hsp90 co-chaperone Cdc37

3

16

High-throughput

0.829

High

1375022

PAK
Serine/threonine-protein kinase Pak

1

11

High-throughput

0.621

High

264530

O62602
mitogen-activated protein kinase kinase

1

17

High-throughput

0.618

High

534457

ACT1
Actin-5C

1

11

High-throughput

0.618

High

823774

SQH
Myosin regulatory light chain sqh

1

3

High-throughput

0.618

High

1064226

SQD
RNA-binding protein squid

1

13

High-throughput

0.618

High

1176055

DJTID
DnaJ homolog l(2)tid, mitochondrial

1

6

High-throughput

0.618

High

1269963

Q7KV89
Mitogen-activated protein kinase kinase kinase kinase

1

17

High-throughput

0.618

High

1375020

Q9VFV9
DnaJ-like-2, isoform A

1

9

High-throughput

0.618

High

1265383

Q7K2L7
GH27120p

1

2

High-throughput

0.553

High

1375035

Q9VZE4
RE70333p

1

9

High-throughput

0.553

High

1375036

FBXW7
F-box/WD repeat-containing protein 7

1

7

High-throughput

0.494

High

1375027

EXOC2
Exocyst complex component 2

1

0

High-throughput

0.486

High

1375017

Q9V470
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

5

High-throughput

0.481

High

122114

M9PHL6
Bifocal, isoform E

1

1

High-throughput

0.479

High

264607

KPYK
Pyruvate kinase

1

1

High-throughput

0.479

High

475813

EF1A1
Elongation factor 1-alpha 1

1

5

High-throughput

0.479

High

476476

TBB3
Tubulin beta-3 chain

1

20

High-throughput

0.479

High

554093

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.479

High

559053

PP12
Serine/threonine-protein phosphatase alpha-2 isoform

1

10

High-throughput

0.479

High

709550

1433Z
14-3-3 protein zeta

1

20

High-throughput

0.479

High

715365

BIP
Endoplasmic reticulum chaperone BiP

1

17

High-throughput

0.479

High

786376

2ABA
Protein phosphatase PP2A 55 kDa regulatory subunit

1

5

High-throughput

0.479

High

958873

ARF1
ADP-ribosylation factor 1

1

2

High-throughput

0.479

High

1038241

IF4A
Eukaryotic initiation factor 4A

1

16

High-throughput

0.479

High

1069745

Q0E931
GTP-binding protein 1

1

10

High-throughput

0.479

High

1172895

RS5A
Small ribosomal subunit protein uS7A

1

4

High-throughput

0.479

High

1174593

TBB1
Tubulin beta-1 chain

1

20

High-throughput

0.479

High

1176079

DX39B
ATP-dependent RNA helicase WM6

1

15

High-throughput

0.479

High

1267251

Q7KKI0
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.479

High

1268221

Q7KN97
Pyruvate carboxylase

1

11

High-throughput

0.479

High

1321379

Q8MST5
Tubulin beta chain

1

20

High-throughput

0.479

High

1375010

Q94883
DNA replication-related element factor, isoform A

1

1

High-throughput

0.479

High

1375011

LDH
L-lactate dehydrogenase

1

3

High-throughput

0.479

High

1375012

FAXC
Failed axon connections

1

1

High-throughput

0.479

High

1375014

Q95U38
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

5

High-throughput

0.479

High

1375015

Q9V434
Asparagine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

1375016

Q9V455
Importin subunit alpha

1

4

High-throughput

0.479

High

1375019

Q9VEC6
LD29902p

1

3

Small-scale

0.479

High

1375021

IPO9
Importin-9

1

10

High-throughput

0.479

High

1375023

Q9VK69
T-complex protein 1 subunit delta

1

20

Small-scale

0.479

High

1375024

NFS1
Cysteine desulfurase, mitochondrial

1

6

High-throughput

0.479

High

1375026

Q9VLC5
aldehyde dehydrogenase

1

2

High-throughput

0.479

High

1375028

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

3

High-throughput

0.479

High

1375038

GALE
UDP-glucose 4-epimerase

1

1

High-throughput

0.479

High

1375043

Q9W437
Raptor, isoform B

1

11

High-throughput

0.479

High

1375044

MCM7
DNA replication licensing factor Mcm7

1

1

High-throughput

0.479

High

1375039

Q9W1N3
Levy, isoform A

1

0

High-throughput

0.458

High

380886

H2B
Histone H2B

1

20

Small-scale

0.457

High

122249

M9PHZ3
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

1

High-throughput

0.439

High

1375034

Q9VXR9
FI03680p

1

1

High-throughput

0.439

High

120780

M9PE30
Transgelin

1

3

High-throughput

0.437

High

264637

COPB2
Coatomer subunit beta'

1

5

High-throughput

0.437

High

715123

CLH
Clathrin heavy chain

1

3

High-throughput

0.437

High

1174410

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.437

High

1266260

Q7K485
Cathepsin D

1

1

High-throughput

0.437

High

1268035

Q7KN75
Dodeca-satellite-binding protein 1, isoform A

1

9

High-throughput

0.437

High

1343650

Q8SX89
Kugelkern, isoform A

1

1

High-throughput

0.437

High

1375013

KCMF1
E3 ubiquitin-protein ligase Kcmf1

1

2

High-throughput

0.437

High

1375018

Q9VDT1
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

1

3

High-throughput

0.437

High

1375025

Q9VKZ7
Nicalin

1

1

High-throughput

0.437

High

1375029

GALL2
MIP18 family protein galla-2

1

2

High-throughput

0.437

High

1375030

Q9VUZ0
Translocon-associated protein subunit beta

1

1

High-throughput

0.437

High

1375031

Q9VV75
AT02348p

1

2

High-throughput

0.437

High

1375033

Q9VWL0
Mec2

1

4

High-throughput

0.437

High

1375037

Q9W0B8
Coatomer subunit alpha

1

5

High-throughput

0.437

High

1375040

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.437

High

1375041

CAPZA
F-actin-capping protein subunit alpha

1

3

High-throughput

0.437

High

1375042

Q9W335
Translocon-associated protein subunit alpha

1

2

High-throughput

0.437

High

1375032

Q9VWE4
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

1

High-throughput

0.417

High

1374780

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

1375045

Q9XZ31
Anastral spindle 2, isoform A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025