HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: LMBL2 (Q969R5)
Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2)
Gene: L3MBTL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	27705803, 28514442, 33961781, 34709266, unassigned3799
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0010629 - negative regulation of gene expression GO:0045892 - negative regulation of DNA-templated transcription GO:1990841 - promoter-specific chromatin binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 705
+	Hs
		1368035 HDAC2_HUMAN (1-478): 0: 666: 85.92		LMBL2_HUMAN (1-705): 0: 1012: 100.00
+	Mm
		148668 HDAC1_MOUSE (1-482): 0: 672: 99.38		LMBL2_MOUSE (1-705): 0: 1001: 90.92
+	Mm
		947424 HDAC2_MOUSE (1-478): 0: 664: 85.71		LMBL2_MOUSE (1-705): 0: 1001: 90.92
+	Hs
		188334 HDAC3_HUMAN (9-434): 0: 574: 57.94		LMBL2_HUMAN (1-705): 0: 1012: 100.00
+	Hs
		1110156 HDAC1_HUMAN (1-482): 0: 668: 100.00		SMBT1_HUMAN (160-638): 0: 556: 32.19
+	Hs
		1368187 HDAC2_HUMAN (1-478): 0: 666: 85.92		SMBT1_HUMAN (160-638): 0: 556: 32.19
+	Dm
		1374481 HDAC1_DROME (6-477): 0: 658: 77.33		SMBT_DROME (138-401): 4.86e-35: 145: 21.17
+	Hs
		1109989 HDAC1_HUMAN (1-482): 0: 668: 100.00		LMBL3_HUMAN (140-285): 2.24e-26: 117: 26.03
+	Hs
		1368053 HDAC2_HUMAN (1-478): 0: 666: 85.92		LMBL3_HUMAN (140-285): 2.24e-26: 117: 26.03
+	Dm
		1374474 HDAC1_DROME (6-477): 0: 658: 77.33		Q9VB52_DROME (148-294): 5.54e-17: 87.9: 22.45