Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1
Interactor 2: MBD2 (Q9UBB5)
Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2)
Gene: MBD2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.987 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 12665568, 27173435, 12183469, 10471499, 10444591, 11297506, 17634443, 26496610, 28514442, 24981860, 33961781, 35271311, 31839598, 40437099, 11102443, 21258344, 23752268, 27593931, unassigned3799 |
| Identification Methods | affinity chromatography technology, pull down, biochemical, cross-linking study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Hist_deacetyl~MBD |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000792 - heterochromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm and 7 others more... |
| Homologous interactions | 12 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
