Protein: MB3L2
Methyl-CpG-binding domain protein 3-like 2 (MBD3-like protein 2)

Gene: MB3L2, MBD3L2
Organism: Homo sapiens
Interactions: 40
UniProt ID: Q8NHZ7

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0006346 - DNA methylation-dependent constitutive heterochromatin formation
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0008327 - methyl-CpG binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1295269

P66A
Transcriptional repressor p66-alpha

1

7

High-throughput

0.691

High

1340894

P66B
Transcriptional repressor p66-beta

1

7

High-throughput

0.691

High

352195

MBD3
Methyl-CpG-binding domain protein 3

2

9

Small-scale

0.636

High

316924

MTA2
Metastasis-associated protein MTA2

2

16

Small-scale

0.619

High

1066406

RBBP4
Histone-binding protein RBBP4

2

8

Small-scale

0.619

High

1102606

MTA1
Metastasis-associated protein MTA1

2

16

Small-scale

0.619

High

1109913

HDAC1
Histone deacetylase 1

2

9

Small-scale

0.619

High

1132842

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

18

Small-scale

0.619

High

1158931

RBBP7
Histone-binding protein RBBP7

2

8

Small-scale

0.619

High

1340895

HDAC2
Histone deacetylase 2

2

9

Small-scale

0.619

High

1340897

GASP2
G-protein coupled receptor-associated sorting protein 2

2

0

High-throughput

0.580

High

1340903

MDFI
MyoD family inhibitor

2

0

High-throughput

0.580

High

65107

GG6L9
Golgin subfamily A member 6-like protein 9

2

2

High-throughput

0.553

High

300434

KRT34
Keratin, type I cuticular Ha4

2

2

High-throughput

0.553

High

1277583

K1C27
Keratin, type I cytoskeletal 27

2

2

High-throughput

0.553

High

1330505

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

3

High-throughput

0.553

High

1088463

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

18

High-throughput

0.536

High

1178564

ZN423
Zinc finger protein 423

1

3

High-throughput

0.536

High

1340891

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

18

High-throughput

0.536

High

1340893

ZN296
Zinc finger protein 296

1

8

High-throughput

0.536

High

1340898

ZBT10
Zinc finger and BTB domain-containing protein 10

1

6

High-throughput

0.536

High

1340901

ZN521
Zinc finger protein 521

1

3

High-throughput

0.536

High

1340904

MTA3
Metastasis-associated protein MTA3

1

16

High-throughput

0.536

High

1340905

BC11A
BCL11 transcription factor A

1

8

High-throughput

0.536

High

1340906

ZN219
Zinc finger protein 219

1

3

High-throughput

0.536

High

1340907

MBD2
Methyl-CpG-binding domain protein 2

1

9

Small-scale

0.527

High

286328

ZN821
Zinc finger protein 821

1

0

High-throughput

0.513

High

1340896

PROX1
Prospero homeobox protein 1

1

0

High-throughput

0.513

High

1340902

KCD15
BTB/POZ domain-containing protein KCTD15

1

0

High-throughput

0.513

High

1340908

KLDC2
Kelch domain-containing protein 2

1

0

High-throughput

0.513

High

230075

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

1

High-throughput

0.489

High

1326276

NIN
Ninein

1

1

High-throughput

0.489

High

1340899

SAHH3
Adenosylhomocysteinase 3

1

1

High-throughput

0.489

High

503705

SBK3
Uncharacterized serine/threonine-protein kinase SBK3

2

0

High-throughput

0.316

High

1202483

RUN3A
RUN domain-containing protein 3A

2

0

High-throughput

0.316

High

343696

GGPPS
Geranylgeranyl pyrophosphate synthase

1

0

High-throughput

0.279

Low

1340892

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.279

Low

1186776

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

1140223

DPOD3
DNA polymerase delta subunit 3

1

0

Small-scale

0.261

Low

1340900

CC136
Coiled-coil domain-containing protein 136

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025