Protein: MB3L1
Methyl-CpG-binding domain protein 3-like 1 (MBD3-like protein 1)

Gene: MB3L1, MBD3L1
Organism: Homo sapiens
Interactions: 72
UniProt ID: Q8WWY6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0006346 - DNA methylation-dependent constitutive heterochromatin formation
GO:0008327 - methyl-CpG binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1295273

P66A
Transcriptional repressor p66-alpha

5

7

High-throughput

0.926

High

1359969

P66B
Transcriptional repressor p66-beta

3

7

High-throughput

0.861

High

316931

MTA2
Metastasis-associated protein MTA2

4

16

Small-scale

0.694

High

1066416

RBBP4
Histone-binding protein RBBP4

4

8

Small-scale

0.694

High

1088476

CHD3
Chromodomain-helicase-DNA-binding protein 3

4

18

Small-scale

0.694

High

1102611

MTA1
Metastasis-associated protein MTA1

4

16

Small-scale

0.694

High

1109937

HDAC1
Histone deacetylase 1

4

9

Small-scale

0.694

High

1158941

RBBP7
Histone-binding protein RBBP7

4

8

Small-scale

0.694

High

1359971

HDAC2
Histone deacetylase 2

4

9

Small-scale

0.694

High

155333

CDKA1
Cyclin-dependent kinase 2-associated protein 1

3

5

High-throughput

0.667

High

1132860

CHD4
Chromodomain-helicase-DNA-binding protein 4

3

18

High-throughput

0.667

High

1178565

ZN423
Zinc finger protein 423

3

3

High-throughput

0.667

High

1328881

ZBTB2
Zinc finger and BTB domain-containing protein 2

3

2

High-throughput

0.667

High

1357119

ZN296
Zinc finger protein 296

3

8

High-throughput

0.667

High

1359973

ZN521
Zinc finger protein 521

3

3

High-throughput

0.667

High

1359977

MTA3
Metastasis-associated protein MTA3

3

16

High-throughput

0.667

High

1359982

BC11A
BCL11 transcription factor A

3

8

High-throughput

0.667

High

1359990

ZN219
Zinc finger protein 219

3

3

High-throughput

0.667

High

1330664

BEND7
BEN domain-containing protein 7

3

1

High-throughput

0.609

High

682081

RBTN1
Rhombotin-1

2

2

High-throughput

0.606

High

1347337

LMO3
LIM domain only protein 3

2

2

High-throughput

0.606

High

1359988

NEK6
Serine/threonine-protein kinase Nek6

2

1

High-throughput

0.606

High

1359995

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

1

High-throughput

0.606

High

299843

SNPC5
snRNA-activating protein complex subunit 5

2

0

High-throughput

0.580

High

348881

CLIC3
Chloride intracellular channel protein 3

2

0

High-throughput

0.580

High

574393

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

0

High-throughput

0.580

High

783733

ZNF76
Zinc finger protein 76

2

0

High-throughput

0.580

High

827453

MLH1
DNA mismatch repair protein Mlh1

2

0

High-throughput

0.580

High

1123058

FHL2
Four and a half LIM domains protein 2

2

0

High-throughput

0.580

High

1156083

ZNF77
Zinc finger protein 77

2

0

High-throughput

0.580

High

1359972

GTPB3
5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial

2

0

High-throughput

0.580

High

1359978

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

2

0

High-throughput

0.580

High

1359980

UBL5
Ubiquitin-like protein 5

2

0

High-throughput

0.580

High

1359989

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.580

High

1359992

NXF1
Nuclear RNA export factor 1

2

0

High-throughput

0.580

High

352207

MBD3
Methyl-CpG-binding domain protein 3

1

9

Small-scale

0.573

High

1359991

MBD2
Methyl-CpG-binding domain protein 2

1

9

Small-scale

0.573

High

1271380

KCTD9
BTB/POZ domain-containing protein KCTD9

2

1

High-throughput

0.553

High

1359997

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

2

High-throughput

0.553

High

1359993

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

Small-scale

0.549

High

1351275

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

18

High-throughput

0.536

High

1359987

ZBT20
Zinc finger and BTB domain-containing protein 20

1

2

High-throughput

0.536

High

515647

TPC2A
Trafficking protein particle complex subunit 2

1

1

High-throughput

0.515

High

1359996

ZN639
Zinc finger protein 639

1

0

High-throughput

0.513

High

515720

TPC2B
Trafficking protein particle complex subunit 2B

1

1

High-throughput

0.481

High

1359968

MB3L1
Methyl-CpG-binding domain protein 3-like 1

1

9

High-throughput

0.481

High

1359976

SIN3A
Paired amphipathic helix protein Sin3a

1

4

Small-scale

0.479

High

1193619

Q49AR9
ANKS1A protein

1

1

High-throughput

0.470

High

1359983

BOLA2
BolA-like protein 2

1

0

High-throughput

0.460

High

1359970

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

1

High-throughput

0.439

High

220284

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.316

High

286694

STX11
Syntaxin-11

2

0

High-throughput

0.316

High

907171

SUOX
Sulfite oxidase, mitochondrial

2

0

High-throughput

0.316

High

907877

CLCKA
Chloride channel protein ClC-Ka

2

0

High-throughput

0.316

High

1119765

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

0

High-throughput

0.316

High

1153697

MPPD2
Metallophosphoesterase MPPED2

2

0

High-throughput

0.316

High

1187661

T10IP
Testis-specific protein 10-interacting protein

2

0

High-throughput

0.316

High

1198258

FND3B
Fibronectin type III domain-containing protein 3B

2

0

High-throughput

0.316

High

1207378

EFHC1
EF-hand domain-containing protein 1

2

0

High-throughput

0.316

High

1289254

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.316

High

1315107

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.316

High

1359974

CA074
UPF0739 protein C1orf74

2

0

High-throughput

0.316

High

1359975

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

0

High-throughput

0.316

High

1359979

KIFC3
Kinesin-like protein KIFC3

2

0

High-throughput

0.316

High

1359981

TSG10
Testis-specific gene 10 protein

2

0

High-throughput

0.316

High

1359984

F124B
Protein FAM124B

2

0

High-throughput

0.316

High

1359985

SH24A
SH2 domain-containing protein 4A

2

0

High-throughput

0.316

High

1359994

CTNA3
Catenin alpha-3

2

0

High-throughput

0.316

High

1359998

GPSM3
G-protein-signaling modulator 3

2

0

High-throughput

0.316

High

775

A0A087WZT3
BOLA2-SMG1P6 readthrough

1

0

High-throughput

0.268

Low

1359986

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025