HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: IKZF2 (Q9UKS7)
Zinc finger protein Helios (Ikaros family zinc finger protein 2)
Gene: IKZF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 526
+	Hs
		1368198 HDAC2_HUMAN (1-478): 0: 666: 85.92		IKZF2_HUMAN (1-526): 0: 692: 100.00
+	Hs
		1368113 HDAC2_HUMAN (1-478): 0: 666: 85.92		IKZF4_HUMAN (9-524): 1.45e-163: 478: 54.03
+	Hs
		1104568 HDAC1_HUMAN (1-482): 0: 668: 100.00		IKZF1_HUMAN (31-526): 9.74e-163: 473: 54.20
+	Hs
		1104626 HDAC2_HUMAN (1-478): 0: 666: 85.92		IKZF1_HUMAN (31-526): 9.74e-163: 473: 54.20
+	Hs
		1110174 HDAC1_HUMAN (1-482): 0: 668: 100.00		IKZF3_HUMAN (10-524): 1.43e-158: 463: 46.52
+	Hs
		1368199 HDAC2_HUMAN (1-478): 0: 666: 85.92		IKZF3_HUMAN (10-524): 1.43e-158: 463: 46.52
+	Hs
		188266 HDAC3_HUMAN (9-434): 0: 574: 57.94		IKZF1_HUMAN (31-526): 9.74e-163: 473: 54.20
+	Mm
		148722 HDAC1_MOUSE (1-482): 0: 672: 99.38		Q8C5P6_MOUSE (31-227): 4.21e-78: 248: 66.50
+	Mm
		1000027 HDAC2_MOUSE (1-478): 0: 664: 85.71		Q8C5P6_MOUSE (31-227): 4.21e-78: 248: 66.50
+	Hs
		1356769 HDAC7_HUMAN (10-410): 1.09e-137: 421: 21.56		IKZF4_HUMAN (9-524): 1.45e-163: 478: 54.03
+	Hs
		1104620 HDAC7_HUMAN (10-410): 1.09e-137: 421: 21.56		IKZF1_HUMAN (31-526): 9.74e-163: 473: 54.20
+	Hs
		1356779 HDAC7_HUMAN (10-410): 1.09e-137: 421: 21.56		IKZF3_HUMAN (10-524): 1.43e-158: 463: 46.52
+	Hs
		1110110 HDAC1_HUMAN (1-482): 0: 668: 100.00		PRDM5_HUMAN (114-219): 9.86e-10: 63.2: 29.25