HitPredict

Interactor 1: G5ECY6 (G5ECY6)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (RING-type E3 ubiquitin transferase CHIP)
Gene: chn-1

Interactor 2: HSP1 (P09446)
Heat shock protein hsp-1 (Heat shock 70 kDa protein A)
Gene: hsp-1

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	15294159, 36027913, 20047968
Identification Methods	two hybrid, pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HSP70~TPR_8
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 266 Ce			1 640
+	Hs
		761538 CHIP_HUMAN (2-257): 6.64e-55: 180: 38.63		HS71L_HUMAN (2-640): 0: 959: 80.60
+	Hs
		600961 CHIP_HUMAN (2-257): 6.64e-55: 180: 38.63		HSP76_HUMAN (2-640): 0: 951: 77.22
+	Mm
		989295 CHIP_MOUSE (2-257): 2.04e-55: 182: 38.27		HSP7C_MOUSE (1-614): 0: 948: 86.32
+	Mm
		609035 CHIP_MOUSE (2-257): 2.04e-55: 182: 38.27		HS71B_MOUSE (1-640): 0: 947: 80.09
+	Hs
		538114 CHIP_HUMAN (2-257): 6.64e-55: 180: 38.63		HSP7C_HUMAN (1-614): 0: 948: 86.32
+	Hs
		516219 CHIP_HUMAN (2-257): 6.64e-55: 180: 38.63		HS71B_HUMAN (1-640): 0: 940: 81.46
+	At
		1441395 CHIP_ARATH (2-258): 5.99e-52: 172: 31.09		HS704_ARATH (2-640): 0: 943: 76.01
+	Hs
		931160 CHIP_HUMAN (2-257): 6.64e-55: 180: 38.63		HSP72_HUMAN (2-640): 0: 932: 81.12
+	Dm
		538299 Q9XYW6_DROME (7-258): 3.66e-53: 175: 36.90		HSP7D_DROME (1-613): 0: 932: 84.18
+	Hs
		600777 PPP5_HUMAN (4-225): 3.3e-36: 136: 18.39		HSP76_HUMAN (2-640): 0: 951: 77.22
+	Hs
		536809 PPP5_HUMAN (4-225): 3.3e-36: 136: 18.39		HSP7C_HUMAN (1-614): 0: 948: 86.32
+	Mm
		989249 PPP5_MOUSE (4-217): 3.33e-36: 136: 18.18		HSP7C_MOUSE (1-614): 0: 948: 86.32
+	Hs
		600897 SGTB_HUMAN (1-158): 9.44e-34: 125: 17.28		HSP76_HUMAN (2-640): 0: 951: 77.22
+	At
		653949 OE64C_ARATH (3-117): 1.39e-33: 130: 27.59		HS701_ARATH (2-640): 0: 944: 75.27
+	At
		103773 OE64M_ARATH (2-119): 2.89e-33: 129: 26.89		HS701_ARATH (2-640): 0: 944: 75.27
+	Hs
		226689 SGTA_HUMAN (2-121): 4.71e-33: 124: 27.27		HSP7C_HUMAN (1-614): 0: 948: 86.32
+	Mm
		989266 SGTA_MOUSE (2-121): 8.28e-33: 123: 27.27		HSP7C_MOUSE (1-614): 0: 948: 86.32
+	Hs
		600938 RPAP3_HUMAN (3-209): 2.92e-28: 114: 17.79		HSP76_HUMAN (2-640): 0: 951: 77.22
+	Dm
		538259 Q9V3E9_DROME (4-209): 4.75e-33: 128: 17.31		HSP7D_DROME (1-613): 0: 932: 84.18
+	Dm
		538272 Q9VJD4_DROME (3-189): 4.32e-34: 127: 18.62		HSP7D_DROME (1-613): 0: 932: 84.18