HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: ANFY1 (Q9P2R3)
Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif)
Gene: ANKFY1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	29038302, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Cullin, BTB~Cullin
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1169
+	Hs
		1115111 CUL4A_HUMAN (10-768): 0: 801: 38.32		ANFY1_HUMAN (1-1169): 0: 712: 100.00
+	Hs
		1113716 CUL3_HUMAN (1-768): 0: 943: 100.00		ANR52_HUMAN (5-764): 1.21e-78: 282: 14.43
+	Hs
		177215 CUL3_HUMAN (1-768): 0: 943: 100.00		ANR28_HUMAN (6-676): 1.95e-68: 252: 16.13
+	Hs
		1091393 CUL3_HUMAN (1-768): 0: 943: 100.00		ANK3_HUMAN (1-510): 1.19e-53: 208: 14.85
+	Hs
		1114688 CUL3_HUMAN (1-768): 0: 943: 100.00		INVS_HUMAN (2-613): 9.84e-50: 194: 15.64
+	Hs
		592933 CUL3_HUMAN (1-768): 0: 943: 100.00		ANK1_HUMAN (2-355): 8.21e-26: 117: 12.96
+	Hs
		1113629 CUL3_HUMAN (1-768): 0: 943: 100.00		ANKH1_HUMAN (5-310): 1.71e-19: 97.6: 11.01
+	Hs
		1091394 CUL4A_HUMAN (10-768): 0: 801: 38.32		ANK3_HUMAN (1-510): 1.19e-53: 208: 14.85
+	Hs
		1371859 CUL5_HUMAN (25-768): 0: 597: 23.77		TNKS2_HUMAN (2-530): 4.87e-47: 186: 15.33