HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: NFASC (Q810U3)
Neurofascin
Gene: NFASC

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	27507650, 28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~fn3, Ank_2~I-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1730 Mm			1 1240
+	Mm
		1115994 SHAN3_MOUSE (1-1730): 0: 626: 100.00		NRCAM_MOUSE (1-1239): 0: 740: 44.50
+	Dm
		590046 Q24241_DROME (25-648): 4.25e-93: 336: 15.33		NRG_DROME (32-1234): 7.09e-175: 553: 26.01
+	Hs
		131996 ANK3_HUMAN (12-592): 2.9e-68: 258: 15.01		NCHL1_HUMAN (5-1235): 0: 630: 32.86
+	Mm
		524113 SHAN3_MOUSE (1-1730): 0: 626: 100.00		CNTN1_MOUSE (17-815): 1.04e-66: 247: 16.47
+	Dm
		65549 A8JNM5_DROME (19-638): 1.13e-74: 279: 14.72		NRG_DROME (32-1234): 7.09e-175: 553: 26.01
+	Hs
		131992 ANK1_HUMAN (175-669): 2.17e-43: 176: 15.35		NCHL1_HUMAN (5-1235): 0: 630: 32.86
+	Hs
		131995 ANK2_HUMAN (212-349): 7.67e-29: 129: 24.64		NCHL1_HUMAN (5-1235): 0: 630: 32.86
+	Rn
		88577 SHAN2_RAT (352-1727): 7.52e-89: 322: 35.92		D3ZDA6_RAT (52-1231): 1.44e-76: 281: 14.27
+	Hs
		1103473 Q9H4D1_HUMAN (1-279): 6.7e-66: 242: 18.21		PRTG_HUMAN (16-373): 1.95e-16: 87.1: 11.72
+	Hs
		883522 RIPK4_HUMAN (1-279): 5.68e-65: 240: 18.21		PRTG_HUMAN (16-373): 1.95e-16: 87.1: 11.72
+	Ce
		1089798 Q8MQG0_CAEEL (203-592): 6.2e-36: 152: 14.62		Q18100_CAEEL (24-341): 1.19e-29: 130: 19.76
+	Hs
		685308 ANK2_HUMAN (212-349): 7.67e-29: 129: 24.64		L1CAM_HUMAN (1-700): 8.63e-25: 114: 11.52