HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: RTN4 (Q99P72)
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)
Gene: RTN4

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36417873
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0014069 - postsynaptic density GO:0043005 - neuron projection GO:0044877 - protein-containing complex binding GO:0050804 - modulation of chemical synaptic transmission GO:0098978 - glutamatergic synapse
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1730 Mm			1 1162
+	Hs
		307110 SHAN3_HUMAN (1-1730): 0: 601: 95.21		RTN3_HUMAN (306-1161): 1.66e-57: 218: 22.22
+	Mm
		93248 SHAN3_MOUSE (1-1730): 0: 626: 100.00		E9PWQ7_MOUSE (5-499): 6.78e-22: 105: 10.30
+	Mm
		292327 SHAN3_MOUSE (1-1730): 0: 626: 100.00		ZAN_MOUSE (5-377): 1.78e-16: 87.8: 9.97
+	Mm
		936894 SHAN3_MOUSE (1-1730): 0: 626: 100.00		NACAM_MOUSE (89-989): 3.82e-15: 83.2: 7.72
+	Mm
		1116160 SHAN3_MOUSE (1-1730): 0: 626: 100.00		PCLO_MOUSE (3-978): 4.94e-13: 76.3: 7.42
+	Hs
		258887 TNKS1_HUMAN (12-400): 2.92e-79: 291: 16.63		RTN2_HUMAN (633-1155): 2.32e-50: 189: 24.81
+	Hs
		1115387 AKD1A_HUMAN (21-460): 3.05e-91: 309: 15.61		TITIN_HUMAN (2-1003): 6.42e-13: 76.2: 10.50
+	Hs
		556716 ANK1_HUMAN (175-669): 2.17e-43: 176: 15.35		TITIN_HUMAN (2-1003): 6.42e-13: 76.2: 10.50
+	Hs
		166985 ANR28_HUMAN (224-592): 3.91e-43: 174: 14.60		TITIN_HUMAN (2-1003): 6.42e-13: 76.2: 10.50
+	Dm
		113976 M9PB30_DROME (662-1371): 7.2e-27: 122: 15.27		M9PB30_DROME (8-673): 1.91e-27: 123: 10.57