HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: PLCB1 (Q9Z1B3)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-beta-1) (PLC-beta-1)
Gene: PLCB1

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	27507650, 28671696, 28469556
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007612 - learning GO:0007613 - memory GO:0098978 - glutamatergic synapse
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1730 Mm			1 1216
+	Rn
		1307759 SHAN2_RAT (352-1727): 7.52e-89: 322: 35.92		PLCB3_RAT (1-1207): 0: 1005: 52.30
+	Hs
		253283 TNKS1_HUMAN (12-400): 2.92e-79: 291: 16.63		PLCH2_HUMAN (14-784): 0: 828: 27.42
+	Hs
		1232252 ANR52_HUMAN (14-494): 3.38e-78: 284: 16.60		PLCD3_HUMAN (5-797): 0: 742: 27.27
+	Hs
		581050 SHAN3_HUMAN (1-1730): 0: 601: 95.21		PLCG1_HUMAN (499-791): 3.1e-78: 284: 31.56
+	Hs
		581080 SHAN2_HUMAN (8-1727): 2.64e-135: 466: 40.52		PLCG1_HUMAN (499-791): 3.1e-78: 284: 31.56