Protein: LRRF2
Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2)

Gene: LRRF2, LRRFIP2
Organism: Homo sapiens
Interactions: 116
UniProt ID: Q9Y608

Gene Ontology (top 5):
GO:0006355 - regulation of DNA-templated transcription
GO:0016055 - Wnt signaling pathway
GO:0030275 - LRR domain binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

702068

TMOD1
Tropomodulin-1

5

12

High-throughput

0.650

High

1491788

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

18

High-throughput

0.618

High

1093342

FLII
Protein flightless-1 homolog

3

11

Small-scale

0.607

High

564619

CFTR
Cystic fibrosis transmembrane conductance regulator

3

14

High-throughput

0.604

High

1452695

TMOD3
Tropomodulin-3

2

13

High-throughput

0.574

High

1453571

TMOD4
Tropomodulin-4

2

12

High-throughput

0.574

High

773106

MYH9
Myosin-9

2

17

High-throughput

0.558

High

1407686

MYD88
Myeloid differentiation primary response protein MyD88

2

4

Small-scale

0.533

High

1447513

ANLN
Anillin

2

9

High-throughput

0.533

High

827977

STAT3
Signal transducer and activator of transcription 3

1

0

High-throughput

0.513

High

248450

NMD3B
Glutamate receptor ionotropic, NMDA 3B

1

5

High-throughput

0.489

High

258621

SH21A
SH2 domain-containing protein 1A

1

20

High-throughput

0.489

High

456069

CRGD
Gamma-crystallin D

1

1

High-throughput

0.489

High

618753

ML12A
Myosin regulatory light chain 12A

1

20

High-throughput

0.489

High

625856

RXRA
Retinoic acid receptor RXR-alpha

1

19

High-throughput

0.489

High

668093

CDK2
Cyclin-dependent kinase 2

1

15

High-throughput

0.489

High

822178

PSB10
Proteasome subunit beta type-10

1

2

High-throughput

0.489

High

863050

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

7

High-throughput

0.489

High

867563

CAPZB
F-actin-capping protein subunit beta

1

7

High-throughput

0.489

High

993404

ACTG
Actin, cytoplasmic 2

1

20

High-throughput

0.489

High

1124772

SRC8
Src substrate cortactin

1

18

High-throughput

0.489

High

1160813

DREB
Drebrin

1

8

High-throughput

0.489

High

1272016

CENPQ
Centromere protein Q

1

2

High-throughput

0.489

High

1322400

ABRA
Actin-binding Rho-activating protein

1

1

High-throughput

0.489

High

1325474

SYNPO
Synaptopodin

1

6

High-throughput

0.489

High

1365630

MY18A
Unconventional myosin-XVIIIa

1

17

High-throughput

0.489

High

1391678

VMP1
Vacuole membrane protein 1

1

1

High-throughput

0.489

High

1392707

MYO19
Unconventional myosin-XIX

1

18

High-throughput

0.489

High

1447573

MYO5C
Unconventional myosin-Vc

1

18

High-throughput

0.489

High

373637

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.479

High

1045957

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

1358002

RN138
E3 ubiquitin-protein ligase RNF138

1

12

High-throughput

0.479

High

1459482

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1462376

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

4

High-throughput

0.479

High

1490499

RNF6
E3 ubiquitin-protein ligase RNF6

1

9

High-throughput

0.479

High

1491360

TRRAP
Transformation/transcription domain-associated protein

1

5

High-throughput

0.479

High

446194

PYGL
Glycogen phosphorylase, liver form

1

1

High-throughput

0.470

High

1163319

H2B2E
Histone H2B type 2-E

1

16

High-throughput

0.470

High

1277809

MYH14
Myosin-14

1

17

High-throughput

0.470

High

186150

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.457

High

126898

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.437

High

136159

PLK4
Serine/threonine-protein kinase PLK4

1

13

Small-scale

0.437

High

178455

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.437

High

179269

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

8

Small-scale

0.437

High

182009

UBD
Ubiquitin D

1

12

Small-scale

0.437

High

243430

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.437

High

294600

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

297719

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

High-throughput

0.437

High

323627

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.437

High

346572

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.437

High

378215

TNFA
Tumor necrosis factor

1

2

High-throughput

0.437

High

401779

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

15

High-throughput

0.437

High

425693

ISG15
Ubiquitin-like protein ISG15

1

12

High-throughput

0.437

High

473230

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

4

High-throughput

0.437

High

538183

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.437

High

630118

BTF3
Transcription factor BTF3

1

6

High-throughput

0.437

High

693153

DPP4
Dipeptidyl peptidase 4

1

4

High-throughput

0.437

High

765157

CTNB1
Catenin beta-1

1

9

High-throughput

0.437

High

786959

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

11

High-throughput

0.437

High

831732

CCNF
Cyclin-F

1

3

High-throughput

0.437

High

837923

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

4

High-throughput

0.437

High

866889

CAZA2
F-actin-capping protein subunit alpha-2

1

8

High-throughput

0.437

High

898043

CDK9
Cyclin-dependent kinase 9

1

18

High-throughput

0.437

High

907642

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

16

High-throughput

0.437

High

941108

HDAC4
Histone deacetylase 4

1

18

High-throughput

0.437

High

953217

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.437

High

972184

1433E
14-3-3 protein epsilon

1

5

Small-scale

0.437

High

995923

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.437

High

1024971

VIGLN
Vigilin

1

3

High-throughput

0.437

High

1116177

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.437

High

1118207

DX39B
Spliceosome RNA helicase DDX39B

1

5

High-throughput

0.437

High

1121389

TRI14
Tripartite motif-containing protein 14

1

7

High-throughput

0.437

High

1138204

TNIP1
TNFAIP3-interacting protein 1

1

18

High-throughput

0.437

High

1141118

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.437

High

1161784

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.437

High

1197612

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

8

High-throughput

0.437

High

1220914

RN123
E3 ubiquitin-protein ligase RNF123

1

9

High-throughput

0.437

High

1227796

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.437

High

1253254

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

20

High-throughput

0.437

High

1256291

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.437

High

1352875

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.437

High

1371484

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

9

Small-scale

0.437

High

1396884

SNX27
Sorting nexin-27

1

12

High-throughput

0.437

High

1417861

RNF26
E3 ubiquitin-protein ligase RNF26

1

1

High-throughput

0.437

High

1419445

RHBT2
Rho-related BTB domain-containing protein 2

1

20

High-throughput

0.437

High

1428445

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.437

High

1450923

RNF12
E3 ubiquitin-protein ligase RLIM

1

9

High-throughput

0.437

High

1458573

HDAC6
Protein deacetylase HDAC6

1

18

High-throughput

0.437

High

1459648

Z3H7B
Zinc finger CCCH domain-containing protein 7B

1

10

High-throughput

0.437

High

1461741

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.437

High

169172

ML12B
Myosin regulatory light chain 12B

1

20

High-throughput

0.407

High

255339

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.407

High

344383

PTBP3
Polypyrimidine tract-binding protein 3

1

2

High-throughput

0.407

High

516610

CALM3
Calmodulin-3

1

2

High-throughput

0.407

High

530674

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.407

High

567230

PPA5
Tartrate-resistant acid phosphatase type 5

1

1

High-throughput

0.407

High

584056

FOSL1
Fos-related antigen 1

1

1

High-throughput

0.407

High

635921

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

1

High-throughput

0.407

High

935360

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.407

High

942984

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

High-throughput

0.407

High

988071

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.407

High

1103480

CTBP1
C-terminal-binding protein 1

1

5

High-throughput

0.407

High

1250155

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

2

Small-scale

0.407

High

1286598

SDCG8
Serologically defined colon cancer antigen 8

1

18

Small-scale

0.407

High

1382359

RN166
E3 ubiquitin-protein ligase RNF166

1

12

High-throughput

0.407

High

1405550

ZBT18
Zinc finger and BTB domain-containing protein 18

1

3

High-throughput

0.407

High

1420785

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

1328091

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

3

0

High-throughput

0.356

High

1139706

SYK
Lysine--tRNA ligase

2

0

High-throughput

0.328

High

1039122

RASF7
Ras association domain-containing protein 7

1

0

High-throughput

0.279

Low

1200200

SMUG1
Single-strand selective monofunctional uracil DNA glycosylase

1

0

High-throughput

0.279

Low

1331808

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

1415456

TM147
BOS complex subunit TMEM147

1

0

High-throughput

0.279

Low

854974

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.249

Low

1041718

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025