HitPredict

Interactor 1: RASF5 (Q5EBH1)
Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL)
Gene: Rassf5

Interactor 2: STK4 (Q9JI11)
Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
Gene: STK4

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.40	1.00	0.638

Property	Details
Experiments	16892067
Identification Methods	anti bait coimmunoprecipitation, fluorescence microscopy
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Pkinase, Mst1_SARAH~Nore1-SARAH, Nore1-SARAH~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006915 - apoptotic process
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 413 Mm			1 487
+	Hs
		1023084 RASF5_HUMAN (1-413): 0: 557: 85.10		STK4_HUMAN (1-487): 1.23e-171: 493: 97.33
+	Hs
		1027406 RASF5_HUMAN (1-413): 0: 557: 85.10		STK3_HUMAN (1-487): 3.56e-152: 444: 72.27
+	Hs
		1023125 RASF1_HUMAN (82-405): 1.5e-140: 406: 45.56		STK4_HUMAN (1-487): 1.23e-171: 493: 97.33
+	Hs
		1027444 RASF1_HUMAN (82-405): 1.5e-140: 406: 45.56		STK3_HUMAN (1-487): 3.56e-152: 444: 72.27
+	Hs
		682035 RASF1_HUMAN (82-405): 1.5e-140: 406: 45.56		AKT1_HUMAN (3-352): 6.52e-130: 387: 21.05
+	Hs
		1023077 RASF3_HUMAN (175-408): 1.1e-82: 255: 46.15		STK4_HUMAN (1-487): 1.23e-171: 493: 97.33
+	Hs
		1027396 RASF3_HUMAN (175-408): 1.1e-82: 255: 46.15		STK3_HUMAN (1-487): 3.56e-152: 444: 72.27
+	Hs
		1023066 RASF6_HUMAN (247-406): 1.65e-57: 194: 25.88		STK4_HUMAN (1-487): 1.23e-171: 493: 97.33
+	Hs
		841548 RASF2_HUMAN (245-413): 6.48e-54: 183: 28.49		STK4_HUMAN (1-487): 1.23e-171: 493: 97.33
+	Hs
		1027388 RASF6_HUMAN (247-406): 1.65e-57: 194: 25.88		STK3_HUMAN (1-487): 3.56e-152: 444: 72.27
+	Hs
		1023109 RASF4_HUMAN (173-410): 1.55e-35: 134: 25.00		STK4_HUMAN (1-487): 1.23e-171: 493: 97.33
+	Hs
		841549 RASF2_HUMAN (245-413): 6.48e-54: 183: 28.49		STK3_HUMAN (1-487): 3.56e-152: 444: 72.27
+	Hs
		1027429 RASF4_HUMAN (173-410): 1.55e-35: 134: 25.00		STK3_HUMAN (1-487): 3.56e-152: 444: 72.27
+	Dm
		1249837 Q9VCQ7_DROME (71-409): 9.28e-109: 339: 21.02		HIPPO_DROME (429-486): 3.78e-11: 67.6: 51.72