HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: TBB6 (Q9BUF5)
Tubulin beta-6 chain (Tubulin beta class V)
Gene: TUBB6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.562

Property	Details
Experiments	unassigned1853, 24275654
Identification Methods	anti tag coimmunoprecipitation, two hybrid
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005737 - cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 446
+	Hs
		1037252 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB3_HUMAN (1-446): 0: 727: 92.38
+	Hs
		428247 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB5_HUMAN (1-429): 0: 719: 92.54
+	Hs
		1130537 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB2B_HUMAN (1-430): 0: 717: 92.79
+	Hs
		933841 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB4B_HUMAN (1-427): 0: 717: 92.74
+	Hs
		1046482 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB2A_HUMAN (1-430): 0: 714: 92.56
+	Hs
		381221 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB4A_HUMAN (1-427): 0: 713: 93.44
+	Mm
		1130127 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		TBB4A_MOUSE (1-427): 0: 713: 93.44
+	Hs
		1037439 SHOC2_HUMAN (944-1353): 1.23e-60: 222: 22.27		TBB3_HUMAN (1-446): 0: 727: 92.38
+	Hs
		428238 LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38		TBB5_HUMAN (1-429): 0: 719: 92.54
+	Hs
		933832 LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38		TBB4B_HUMAN (1-427): 0: 717: 92.74
+	Hs
		201179 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		TBB5_HUMAN (1-429): 0: 719: 92.54
+	Hs
		201419 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		TBB2B_HUMAN (1-430): 0: 717: 92.79
+	Hs
		201171 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		TBB4A_HUMAN (1-427): 0: 713: 93.44