HitPredict

Interactor 1: MPP7 (Q5T2T1)
MAGUK p55 subfamily member 7
Gene: MPP7

Interactor 2: LIN7C (Q9NUP9)
Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)
Gene: LIN7C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.926

Property	Details
Experiments	26186194, 28514442, 32296183, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, validated two hybrid, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, L27~L27, PDZ~PDZ
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0005923 - bicellular tight junction GO:0019904 - protein domain specific binding GO:0097025 - MPP7-DLG1-LIN7 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 576 Hs			1 197
+	Hs
		1132892 MPP7_HUMAN (1-576): 5.36e-166: 486: 100.00		LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69
+	Hs
		158288 MPP7_HUMAN (1-576): 5.36e-166: 486: 100.00		LIN7A_HUMAN (6-194): 4.87e-51: 166: 80.42
+	Dm
		116476 M9PJD0_DROME (10-576): 1.01e-148: 472: 30.57		Q9VBY7_DROME (1-195): 1.45e-52: 168: 80.00
+	Hs
		663981 MPP7_HUMAN (1-576): 5.36e-166: 486: 100.00		PTN4_HUMAN (43-187): 5.75e-33: 126: 29.14
+	Hs
		1032762 MPP3_HUMAN (1-574): 8.99e-144: 429: 53.10		LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00
+	Hs
		1050418 MPP2_HUMAN (1-575): 7.4e-142: 424: 33.88		LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00
+	Hs
		1032760 MPP3_HUMAN (1-574): 8.99e-144: 429: 53.10		LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69
+	Dm
		53140 A1Z8G0_DROME (3-575): 3.98e-146: 435: 38.76		Q9VBY7_DROME (1-195): 1.45e-52: 168: 80.00
+	Hs
		1050415 MPP2_HUMAN (1-575): 7.4e-142: 424: 33.88		LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69
+	Hs
		1334778 PALS2_HUMAN (14-575): 3.59e-142: 424: 34.21		LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69
+	Hs
		158279 MPP3_HUMAN (1-574): 8.99e-144: 429: 53.10		LIN7A_HUMAN (6-194): 4.87e-51: 166: 80.42
+	Dm
		1250379 Q8T5S9_DROME (3-575): 1.53e-142: 425: 38.63		Q9VBY7_DROME (1-195): 1.45e-52: 168: 80.00
+	Hs
		158282 MPP2_HUMAN (1-575): 7.4e-142: 424: 33.88		LIN7A_HUMAN (6-194): 4.87e-51: 166: 80.42
+	Hs
		158304 PALS2_HUMAN (14-575): 3.59e-142: 424: 34.21		LIN7A_HUMAN (6-194): 4.87e-51: 166: 80.42
+	Hs
		1295085 MPP4_HUMAN (4-576): 3.74e-157: 465: 38.29		MPP4_HUMAN (16-174): 1.11e-30: 119: 28.30
+	Hs
		1032764 MPP3_HUMAN (1-574): 8.99e-144: 429: 53.10		SNTG2_HUMAN (28-188): 1.75e-32: 124: 25.77
+	Hs
		1132886 MPP7_HUMAN (1-576): 5.36e-166: 486: 100.00		SNX27_HUMAN (91-175): 2.59e-12: 66.6: 38.14
+	Mm
		1143555 MPP2_MOUSE (1-575): 9.21e-143: 425: 34.76		DLG4_MOUSE (59-195): 8.13e-24: 99.8: 26.76
+	Hs
		1021489 MPP2_HUMAN (1-575): 7.4e-142: 424: 33.88		DLG1_HUMAN (50-178): 8.31e-23: 97.1: 30.60
+	Dm
		53136 A1Z8G0_DROME (3-575): 3.98e-146: 435: 38.76		DLG1_DROME (57-176): 1.06e-14: 73.6: 28.00