HitPredict

Interactor 1: NHRF3 (Q5T2W1)
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)
Gene: PDZK1

Interactor 2: ACE2 (Q9BYF1)
Angiotensin-converting enzyme 2 (EC 3.4.17.23) (Angiotensin-converting enzyme homolog) (ACEH) (Angiotensin-converting enzyme-related carboxypeptidase) (ACE-related carboxypeptidase) (EC 3.4.17.-) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2]
Gene: ACE2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	33436498, 34189428, 34835087
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016324 - apical plasma membrane GO:0031526 - brush border membrane GO:0070062 - extracellular exosome
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 519 Hs			1 805
+	Hs
		153946 NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54		ACE2_HUMAN (12-805): 0: 1184: 100.00
+	Hs
		1050048 SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97		ACE2_HUMAN (12-805): 0: 1184: 100.00
+	Hs
		1075451 NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17		ACE2_HUMAN (12-805): 0: 1184: 100.00