HitPredict

Interactor 1: TNIP1 (Q15025)
TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN)
Gene: TNIP1

Interactor 2: SMC3 (Q9UQE7)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)
Gene: SMC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36574265
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 1217
+	Hs
		1462729 SMC3_HUMAN (278-527): 2.29e-43: 169: 25.09		SMC3_HUMAN (1-1217): 1.79e-122: 410: 100.00
+	Xl
		313484 SMC3_XENLA (278-527): 4.34e-42: 165: 24.72		SMC3_XENLA (1-1217): 7.25e-120: 402: 95.81
+	Hs
		1130044 TNIP1_HUMAN (1-636): 3.59e-77: 260: 100.00		SMC1A_HUMAN (2-1211): 1.12e-80: 291: 16.52
+	Hs
		1138090 TNIP1_HUMAN (1-636): 3.59e-77: 260: 100.00		SMC4_HUMAN (1-1206): 2.28e-77: 281: 16.77
+	Hs
		776872 MYH11_HUMAN (103-571): 3.81e-18: 91.5: 13.36		SMC3_HUMAN (1-1217): 1.79e-122: 410: 100.00
+	Mm
		1423807 SMC3_MOUSE (278-527): 2.95e-43: 169: 25.09		SMC1A_MOUSE (2-1211): 6.6e-81: 292: 16.52
+	Bt
		357658 SMC3_BOVIN (278-527): 1.92e-43: 170: 25.09		SMC1A_BOVIN (2-1211): 1.12e-80: 291: 16.52
+	Hs
		1130223 SMC3_HUMAN (278-527): 2.29e-43: 169: 25.09		SMC1A_HUMAN (2-1211): 1.12e-80: 291: 16.52
+	Hs
		1336791 SMC3_HUMAN (278-527): 2.29e-43: 169: 25.09		SMC1B_HUMAN (2-1217): 8.37e-75: 273: 14.22
+	Xl
		313481 Q8AW91_XENLA (278-527): 1.43e-42: 167: 24.72		SMC1A_XENLA (2-1211): 4.79e-75: 274: 15.96
+	Xl
		313473 SMC3_XENLA (278-527): 4.34e-42: 165: 24.72		SMC1A_XENLA (2-1211): 4.79e-75: 274: 15.96
+	Hs
		334127 SMC3_HUMAN (278-527): 2.29e-43: 169: 25.09		SMC2_HUMAN (1-1217): 2.53e-73: 268: 18.97
+	Mm
		1362489 SMC3_MOUSE (278-527): 2.95e-43: 169: 25.09		SMC1B_MOUSE (2-1217): 2.38e-71: 263: 13.84
+	Hs
		563081 MYH8_HUMAN (2-454): 1.71e-18: 92.2: 13.13		MYH4_HUMAN (354-1101): 2.04e-24: 113: 9.34
+	Hs
		563078 MYH13_HUMAN (2-539): 6.53e-18: 90.7: 11.29		MYH8_HUMAN (143-798): 1.72e-24: 113: 10.33
+	Hs
		556973 MYH7_HUMAN (2-460): 8.98e-18: 89.9: 10.81		MYH4_HUMAN (354-1101): 2.04e-24: 113: 9.34
+	Mm
		563088 MYH8_MOUSE (15-454): 6.99e-18: 90.3: 12.53		MYH6_MOUSE (581-1114): 2.36e-16: 87: 11.42
+	Mm
		1037830 MYH6_MOUSE (2-470): 1.93e-17: 89.2: 11.20		MYH6_MOUSE (581-1114): 2.36e-16: 87: 11.42
+	Hs
		556892 MYH7_HUMAN (2-460): 8.98e-18: 89.9: 10.81		MYH7_HUMAN (627-1126): 2.95e-15: 83.6: 13.49