HitPredict

Interactor 1: SMC1A (O97593)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1A)
Gene: SMC1A

Interactor 2: SMC3 (O97594)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Chondroitin sulfate proteoglycan 6)
Gene: SMC3

Species: Bos taurus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11564881
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SMC_hinge~SMC_hinge, SMC_N~SMC_N
Common GO terms	GO:0005524 - ATP binding GO:0006281 - DNA repair GO:0016887 - ATP hydrolysis activity GO:0030893 - meiotic cohesin complex GO:0051301 - cell division and 1 others more... GO:0051321 - meiotic cell cycle
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1233 Bt			1 1218
+	Mm
		1423807 SMC1A_MOUSE (1-1233): 7.32e-129: 428: 99.84		SMC3_MOUSE (1-1218): 2.78e-122: 409: 98.44
+	Hs
		1130223 SMC1A_HUMAN (1-1233): 1.4e-128: 427: 99.84		SMC3_HUMAN (1-1218): 4.55e-122: 409: 98.52
+	Xl
		313481 SMC1A_XENLA (1-1232): 1.59e-122: 411: 93.91		Q8AW91_XENLA (1-1218): 6e-123: 411: 95.32
+	Xl
		313473 SMC1A_XENLA (1-1232): 1.59e-122: 411: 93.91		SMC3_XENLA (1-1218): 5.91e-122: 408: 94.75
+	Hs
		1336791 SMC1B_HUMAN (1-1233): 9.79e-111: 378: 53.04		SMC3_HUMAN (1-1218): 4.55e-122: 409: 98.52
+	Mm
		1362489 SMC1B_MOUSE (1-1233): 6.29e-105: 362: 51.83		SMC3_MOUSE (1-1218): 2.78e-122: 409: 98.44
+	Hs
		1130036 SMC1A_HUMAN (1-1233): 1.4e-128: 427: 99.84		SMC1A_HUMAN (2-1212): 4.16e-80: 289: 15.96
+	Hs
		334127 SMC2_HUMAN (3-1214): 1.82e-77: 281: 18.22		SMC3_HUMAN (1-1218): 4.55e-122: 409: 98.52
+	Mm
		1362488 SMC1A_MOUSE (1-1233): 7.32e-129: 428: 99.84		SMC1B_MOUSE (2-1218): 2.16e-70: 260: 14.29
+	Dm
		1267235 Q7KK96_DROME (3-1217): 1.25e-90: 320: 19.33		Q9V3A7_DROME (1-1202): 1.78e-83: 301: 15.66
+	Sc
		864355 SMC3_YEAST (3-1215): 9.21e-78: 282: 18.20		SMC3_YEAST (1-1218): 7.57e-83: 297: 29.69
+	Hs
		334110 SMC2_HUMAN (3-1214): 1.82e-77: 281: 18.22		SMC4_HUMAN (1-1207): 5.38e-79: 286: 16.87
+	Sc
		808594 SMC3_YEAST (3-1215): 9.21e-78: 282: 18.20		SMC2_YEAST (1-1202): 2.67e-72: 265: 19.53
+	Xl
		896119 SMC4_XENLA (4-1211): 3.31e-78: 284: 20.59		SMC2_XENLA (1-1206): 1.53e-70: 260: 18.17
+	Sc
		864388 SMC3_YEAST (3-1215): 9.21e-78: 282: 18.20		SMC4_YEAST (1-1208): 1.56e-70: 261: 16.69
+	Ce
		1068124 SMC4_CAEEL (4-1210): 8.56e-79: 287: 17.66		MIX1_CAEEL (1-1207): 5.4e-66: 246: 17.10
+	Bs
		908314 SMC_BACSU (3-1225): 2.83e-77: 280: 16.68		SMC_BACSU (1-1212): 8.33e-68: 251: 17.75
+	Sc
		747737 SMC3_YEAST (3-1215): 9.21e-78: 282: 18.20		SMC1_YEAST (2-1205): 1.16e-65: 245: 16.91