HitPredict

Interactor 1: U5S1 (Q15029)
116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)
Gene: EFTUD2

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30517763
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 972 Hs			1 903
+	Hs
		132048 U5S1_HUMAN (1-972): 0: 1061: 100.00		WWP2_HUMAN (1-903): 0: 808: 54.18
+	Hs
		1138527 U5S1_HUMAN (1-972): 0: 1061: 100.00		NED4L_HUMAN (6-900): 0: 761: 32.31
+	Hs
		566006 EF2_HUMAN (111-957): 0: 909: 38.04		ITCH_HUMAN (1-903): 0: 913: 100.00
+	Hs
		131704 EF2_HUMAN (111-957): 0: 909: 38.04		WWP2_HUMAN (1-903): 0: 808: 54.18
+	Hs
		1138354 U5S1_HUMAN (1-972): 0: 1061: 100.00		HUWE1_HUMAN (415-902): 8.1e-162: 527: 34.88
+	Mm
		945970 EF2_MOUSE (111-957): 0: 911: 38.04		HUWE1_MOUSE (415-902): 6.63e-162: 527: 34.88
+	Hs
		565955 EF2_HUMAN (111-957): 0: 909: 38.04		HUWE1_HUMAN (415-902): 8.1e-162: 527: 34.88
+	Sc
		734190 EF2_YEAST (111-957): 0: 875: 36.04		TOM1_YEAST (487-902): 1.03e-161: 526: 39.10
+	Hs
		566046 EF2_HUMAN (111-957): 0: 909: 38.04		SMUF1_HUMAN (1-433): 1.57e-45: 177: 16.14
+	Hs
		1401625 EFGM_HUMAN (117-932): 0: 580: 19.52		SMUF2_HUMAN (1-358): 1.14e-42: 168: 17.63