HitPredict

Interactor 1: UBC (Q63429)
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related]
Gene: UBC

Interactor 2: CUL5 (Q9JJ31)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Rattus norvegicus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22871113
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~ubiquitin, Cullin_Nedd8~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0016567 - protein ubiquitination GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 810 Rn			1 780
+	Rn
		78188 UBC_RAT (1-810): 0: 1000: 100.00		CUL3_RAT (8-780): 0: 751: 22.84
+	Rn
		70071 UBC_RAT (1-810): 0: 1000: 100.00		B1WBY1_RAT (4-780): 0: 748: 27.60
+	Rn
		71349 UBC_RAT (1-810): 0: 1000: 100.00		B2RYJ3_RAT (16-780): 0: 743: 25.00
+	Hs
		476148 UBC_HUMAN (1-533): 0: 662: 99.81		CUL5_HUMAN (1-780): 0: 787: 98.72
+	Hs
		475728 UBC_HUMAN (1-533): 0: 662: 99.81		CUL3_HUMAN (8-780): 0: 752: 22.84
+	Hs
		475726 UBC_HUMAN (1-533): 0: 662: 99.81		CUL1_HUMAN (4-780): 0: 748: 27.60
+	Hs
		475729 UBC_HUMAN (1-533): 0: 662: 99.81		CUL4A_HUMAN (16-780): 0: 742: 24.74
+	Hs
		475730 UBC_HUMAN (1-533): 0: 662: 99.81		CUL4B_HUMAN (16-780): 0: 736: 25.78
+	Hs
		475727 UBC_HUMAN (1-533): 0: 662: 99.81		CUL2_HUMAN (10-780): 0: 698: 26.50
+	Sp
		142914 UBI4P_SCHPO (457-801): 1.39e-132: 401: 90.73		CUL1_SCHPO (3-780): 0: 680: 24.35
+	At
		1091919 UBQ3_ARATH (533-801): 1.64e-106: 330: 89.22		CUL1_ARATH (8-780): 0: 720: 24.46
+	Mm
		477002 UBC_MOUSE (1-108): 6.19e-31: 132: 90.74		CUL5_MOUSE (1-780): 0: 790: 99.49
+	Hs
		923983 RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00		CUL3_HUMAN (8-780): 0: 752: 22.84
+	At
		1352191 RUB1_ARATH (685-801): 2.07e-38: 142: 72.65		CUL3A_ARATH (16-780): 0: 753: 22.79
+	Hs
		923984 RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00		CUL4A_HUMAN (16-780): 0: 742: 24.74
+	Hs
		923985 RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00		CUL4B_HUMAN (16-780): 0: 736: 25.78
+	At
		1321116 RUB1_ARATH (685-801): 2.07e-38: 142: 72.65		CUL3B_ARATH (16-780): 0: 741: 22.79
+	At
		1277343 RUB1_ARATH (685-801): 2.07e-38: 142: 72.65		CUL1_ARATH (8-780): 0: 720: 24.46
+	At
		1247030 RUB2_ARATH (685-801): 5.81e-38: 140: 72.65		CUL1_ARATH (8-780): 0: 720: 24.46
+	Mm
		477001 UBC_MOUSE (1-108): 6.19e-31: 132: 90.74		CUL2_MOUSE (10-780): 0: 706: 26.37