HitPredict

Interactor 1: PCH2 (Q15645)
Pachytene checkpoint protein 2 homolog (Human papillomavirus type 16 E1 protein-binding protein) (16E1-BP) (HPV16 E1 protein-binding protein) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13)
Gene: TRIP13

Interactor 2: FBXW8 (Q8N3Y1)
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
Gene: FBXW8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	21572988
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 432 Hs			1 598
+	Hs
		1151035 PCH2_HUMAN (1-432): 5.7e-104: 317: 100.00		FBXW7_HUMAN (417-592): 2.78e-37: 149: 16.85
+	Hs
		845266 PRS8_HUMAN (10-430): 1.89e-89: 279: 15.46		LIS1_HUMAN (4-327): 1.35e-46: 170: 10.77
+	Hs
		845251 PRS6B_HUMAN (3-429): 6.34e-86: 270: 16.40		LIS1_HUMAN (4-327): 1.35e-46: 170: 10.77
+	Hs
		969014 PRS8_HUMAN (10-430): 1.89e-89: 279: 15.46		FBXW7_HUMAN (417-592): 2.78e-37: 149: 16.85
+	Sc
		679683 CDC48_YEAST (51-424): 1.95e-72: 245: 19.75		MET30_YEAST (373-598): 8.81e-44: 167: 12.68
+	Hs
		851440 PRS6B_HUMAN (3-429): 6.34e-86: 270: 16.40		FBW1B_HUMAN (421-593): 3.1e-31: 130: 18.33
+	Hs
		845261 TERA_HUMAN (126-425): 5.43e-64: 221: 19.00		LIS1_HUMAN (4-327): 1.35e-46: 170: 10.77
+	Sc
		460741 PRS8_YEAST (27-423): 6.56e-94: 290: 17.33		CDC4_YEAST (470-554): 1.07e-10: 66.6: 20.46
+	Hs
		935317 TERA_HUMAN (126-425): 5.43e-64: 221: 19.00		FBW1A_HUMAN (421-593): 4.84e-32: 132: 17.22
+	Hs
		935270 TERA_HUMAN (126-425): 5.43e-64: 221: 19.00		FBW1B_HUMAN (421-593): 3.1e-31: 130: 18.33
+	Hs
		964814 PRS10_HUMAN (2-426): 1.02e-90: 281: 17.67		WDR5_HUMAN (110-238): 7.41e-12: 68.8: 9.42
+	Hs
		964801 PRS8_HUMAN (10-430): 1.89e-89: 279: 15.46		WDR5_HUMAN (110-238): 7.41e-12: 68.8: 9.42
+	Hs
		851285 PRS6B_HUMAN (3-429): 6.34e-86: 270: 16.40		WDR5_HUMAN (110-238): 7.41e-12: 68.8: 9.42
+	Hs
		1333215 AFG2A_HUMAN (130-424): 2.07e-55: 198: 21.67		FBW1A_HUMAN (421-593): 4.84e-32: 132: 17.22
+	Hs
		1333211 AFG2A_HUMAN (130-424): 2.07e-55: 198: 21.67		FBW1B_HUMAN (421-593): 3.1e-31: 130: 18.33
+	Dm
		1267936 TERA_DROME (134-425): 1.12e-62: 218: 18.85		Q9VDE3_DROME (113-258): 1.34e-12: 72.2: 10.90
+	Hs
		934381 TERA_HUMAN (126-425): 5.43e-64: 221: 19.00		WDR5_HUMAN (110-238): 7.41e-12: 68.8: 9.42
+	Sc
		673553 AFG2_YEAST (175-338): 1.21e-12: 72: 28.92		NLE1_YEAST (67-235): 1.13e-16: 85.3: 14.29