HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: TESK2 (Q96S53)
Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2)
Gene: TESK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	32707033, 25036637
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDC37_M~PK_Tyr_Ser-Thr, CDC37_N~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 571
+	Hs
		932034 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		EPHB1_HUMAN (4-410): 2.88e-124: 390: 21.80
+	Hs
		710842 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		EPHB2_HUMAN (16-459): 1.27e-122: 388: 18.30
+	Hs
		1088185 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		MERTK_HUMAN (61-437): 2.03e-100: 328: 25.00
+	Hs
		922255 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		LIMK1_HUMAN (62-312): 5.58e-66: 228: 44.40
+	Hs
		922313 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		LIMK2_HUMAN (62-318): 8.88e-61: 214: 40.86